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DNA Gyrase

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Mutant selection window of four quinolone antibiotics against clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 29290527
Community-acquired pneumonia and otitis media are caused by several bacterial species, including Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. For the treatment of these diseases, various quinolones are frequently used....
Anti-Bacterial Agents DNA Gyrase DNA Mutational Analysis DNA Topoisomerase IV Drug Resistance, Bacterial Haemophilus influenzae Humans Microbial Sensitivity Tests Moraxella catarrhalis Otitis Media Pneumonia, Bacterial Quinolones Selection, Genetic Streptococcus pneumoniae
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Design of (quinolin-4-ylthio)carboxylic acids as new Escherichia coli DNA gyrase B inhibitors: machine learning studies, molecular docking, synthesis and biological testing.

Computational biology and chemistry 32018168
Spread of multidrug-resistant Escherichia coli clinical isolates is a main problem in the treatment of infectious diseases. Therefore, the modern scientific approaches in decision this problem require not only a prevention strategy, but also the deve...
Anti-Bacterial Agents Computational Biology DNA Gyrase Drug Design Escherichia coli Machine Learning Microbial Sensitivity Tests Molecular Docking Simulation Molecular Structure Quantitative Structure-Activity Relationship Quinolines Topoisomerase II Inhibitors
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Understanding and predicting ciprofloxacin minimum inhibitory concentration in Escherichia coli with machine learning.

Scientific reports 32929164
It is important that antibiotics prescriptions are based on antimicrobial susceptibility data to ensure effective treatment outcomes. The increasing availability of next-generation sequencing, bacterial whole genome sequencing (WGS) can facilitate a ...
Anti-Bacterial Agents Ciprofloxacin DNA Gyrase Drug Resistance, Bacterial Escherichia coli Escherichia coli Proteins Genes, Bacterial Inhibitory Concentration 50 Intracellular Signaling Peptides and Proteins Machine Learning Mutation Toxicity Tests
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Investigation of bacterial DNA gyrase Inhibitor classification models and structural requirements utilizing multiple machine learning methods.

Molecular diversity 38372837
Infections from multidrug-resistant (MDR) bacteria have emerged as a paramount global health concern, and the therapeutic effectiveness of current treatments is swiftly diminishing. An urgent need exists to explore innovative strategies for counterin...
Anti-Bacterial Agents Bacteria DNA Gyrase Machine Learning Models, Molecular Molecular Docking Simulation Topoisomerase II Inhibitors
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