AIMC Topic: Quinolines
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The Value of Machine Learning-based Radiomics Model Characterized by PET Imaging with Ga-FAPI in Assessing Microvascular Invasion of Hepatocellular Carcinoma.
Academic radiology
Dec 7, 2024
RATIONALE AND OBJECTIVES: This study aimed to develop a radiomics model characterized by Ga-fibroblast activation protein inhibitors (FAPI) positron emission tomography (PET) imaging to predict microvascular invasion (MVI) of hepatocellular carcinoma...
Pretreatment CT-based machine learning radiomics model predicts response in unresectable hepatocellular carcinoma treated with lenvatinib plus PD-1 inhibitors and interventional therapy.
Journal for immunotherapy of cancer
Sep 25, 2024
Pretreatment CT-based machine learning radiomics model predicts response in unresectable hepatocellular carcinoma treated with lenvatinib plus PD-1 inhibitors and interventional therapy.
Journal for immunotherapy of cancer
Jul 18, 2024
BACKGROUND: Lenvatinib plus PD-1 inhibitors and interventional (LPI) therapy have demonstrated promising treatment effects in unresectable hepatocellular carcinoma (HCC). However, biomarkers for predicting the response to LPI therapy remain to be fur...
Synthesis, Docking, and Machine Learning Studies of Some Novel Quinolinesulfonamides-Triazole Hybrids with Anticancer Activity.
Molecules (Basel, Switzerland)
Jul 2, 2024
In the presented work, a series of 22 hybrids of 8-quinolinesulfonamide and 1,4-disubstituted triazole with antiproliferative activity were designed and synthesised. The title compounds were designed using molecular modelling techniques. For this pur...
MedGAN: optimized generative adversarial network with graph convolutional networks for novel molecule design.
Scientific reports
Jan 12, 2024
Generative Artificial Intelligence can be an important asset in the drug discovery process to meet the demand for novel medicines. This work outlines the optimization and fine-tuning steps of MedGAN, a deep learning model based on Wasserstein Generat...
The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID-19- related cough: A randomized, controlled clinical trial.
The clinical respiratory journal
Jul 31, 2022
INTRODUCTION: Cough is one of the most common presenting symptoms of COVID-19, which can persist for weeks or months.
Design of (quinolin-4-ylthio)carboxylic acids as new Escherichia coli DNA gyrase B inhibitors: machine learning studies, molecular docking, synthesis and biological testing.
Computational biology and chemistry
Jan 24, 2020
Spread of multidrug-resistant Escherichia coli clinical isolates is a main problem in the treatment of infectious diseases. Therefore, the modern scientific approaches in decision this problem require not only a prevention strategy, but also the deve...
Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia.
Oxidative medicine and cellular longevity
Dec 18, 2018
Postcardiac arrest syndrome yields poor neurological outcomes, but the mechanisms underlying this condition remain poorly understood. Autophagy plays an important role in neuronal apoptosis induced by ischemia. However, whether autophagy is involved ...
Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae).
Molecules (Basel, Switzerland)
Dec 21, 2017
Three new prenylated furoquinoline alkaloids named lecomtequinoline A (), B (), and C (), together with the known compounds anhydroevoxine (), evoxine (), dictamnine (), methylflindersine (), evoxanthine (), hesperidin, lupeol, -sitosterol, stigmaste...
Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids.
Respiratory medicine
Dec 13, 2017
BACKGROUND: Asthma is a heterogeneous and complex disease in both its clinical course and response to treatment. IL-13 is central to Type 2 inflammation and contributes to many features of asthma. In a previous Phase 2 study, lebrikizumab, an anti-IL...
Male
Middle Aged
Glucocorticoids
Severity of Illness Index
Humans
Quinolines
Female
Administration, Inhalation
Adult
Anti-Asthmatic Agents
Asthma
Double-Blind Method
Forced Expiratory Volume
Acetates
Sulfides
Injections, Subcutaneous
Treatment Failure
Treatment Outcome
Cyclopropanes
Antibodies, Monoclonal
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