AIMC Topic: Dynamins

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Drp1 Proteins Released from Hydrolysis-Driven Scaffold Disassembly Trigger Nucleotide-Dependent Membrane Remodeling to Promote Scission.

Journal of the American Chemical Society Jul 8, 2025
Dynamin-related protein (Drp1) drives mitochondrial fission, dysregulation of which leads to neurodegenerative, metabolic, and apoptotic disorders. The precise mechanism of fission completion is unclear. One prevailing model is based on GTP-driven o...
Humans Hydrolysis Dynamins Guanosine Triphosphate Mitochondrial Dynamics
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Dynamin-like Proteins Combine Mechano-constriction and Membrane Remodeling to Enable Two-Step Mitochondrial Fission via a "Snap-through" Instability.

Journal of the American Chemical Society Jul 8, 2025
Mitochondrial fission is controlled by dynamin-like proteins, the dysregulation of which is correlated with diverse diseases. Fission dynamin-like proteins are GTP hydrolysis-driven mechanoenzymes that self-oligomerize into helical structures that co...
Humans Mitochondria Dynamins Mitochondrial Dynamics
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Machine-Learning-Based Analysis in Genome-Edited Cells Reveals the Efficiency of Clathrin-Mediated Endocytosis.

Cell reports Sep 17, 2015
Cells internalize various molecules through clathrin-mediated endocytosis (CME). Previous live-cell imaging studies suggested that CME is inefficient, with about half of the events terminated. These CME efficiency estimates may have been confounded b...
Humans Female Cell Line, Tumor Support Vector Machine Epithelial Cells Base Sequence Genome, Human Introns Endocytosis Molecular Sequence Data Mammary Glands, Human Exons Adaptor Protein Complex 2 Clathrin Dynamin II Dynamins
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