AIMC Topic: Fluorescence Polarization

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Deep learning-based cell segmentation for rapid optical cytopathology of thyroid cancer.

Scientific reports Jul 16, 2024
Fluorescence polarization (Fpol) imaging of methylene blue (MB) is a promising quantitative approach to thyroid cancer detection. Clinical translation of MB Fpol technology requires reduction of the data analysis time that can be achieved via deep le...
Humans Neural Networks, Computer Deep Learning Thyroid Gland Thyroid Neoplasms Image Processing, Computer-Assisted Cytodiagnosis Fluorescence Polarization Methylene Blue
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Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.

Journal of the American Chemical Society Mar 8, 2021
Macrocycles, including macrocyclic peptides, have shown promise for targeting challenging protein-protein interactions (PPIs). One PPI of high interest is between Kelch-like ECH-Associated Protein-1 (KEAP1) and Nuclear Factor (Erythroid-derived 2)-li...
Humans Machine Learning Peptides Protein Binding Recombinant Proteins Structure-Activity Relationship Crystallography, X-Ray Hydrogen Bonding Fluorescence Polarization Nuclear Magnetic Resonance, Biomolecular NF-E2-Related Factor 2 Mutagenesis, Site-Directed Amino Acid Motifs Cyclization Kelch-Like ECH-Associated Protein 1
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A smartphone-based system for fluorescence polarization assays.

Biosensors & bioelectronics Dec 24, 2018
This paper demonstrates the use of a smartphone-based sensor for fluorescence polarization (FP) analysis of biomolecules. The FP detection can rapidly sense ligand-analyte bindings by measuring molecule mobility, and thus, FP-based assays have been w...
Humans Biomarkers Smartphone Biosensing Techniques Limit of Detection Ligands Lasers Bacterial Toxins Fluorescence Polarization
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