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Histone Deacetylase 1

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PTML Modeling for Alzheimer's Disease: Design and Prediction of Virtual Multi-Target Inhibitors of GSK3B, HDAC1, and HDAC6.

Current topics in medicinal chemistry 32515311
BACKGROUND: Alzheimer's disease is characterized by a progressive pattern of cognitive and functional impairment, which ultimately leads to death. Computational approaches have played an important role in the context of drug discovery for anti-Alzhei...
Alzheimer Disease Drug Design Glycogen Synthase Kinase 3 beta Histone Deacetylase 1 Histone Deacetylase 6 Histone Deacetylase Inhibitors Humans Machine Learning Models, Molecular Molecular Structure Neural Networks, Computer Protein Kinase Inhibitors
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Classification models and SAR analysis on HDAC1 inhibitors using machine learning methods.

Molecular diversity 35737257
Histone deacetylase (HDAC) 1, a member of the histone deacetylases family, plays a pivotal role in various tumors. In this study, we collected 7313 human HDAC1 inhibitors with bioactivities to form a dataset. Then, the dataset was divided into a trai...
Algorithms Histone Deacetylase 1 Humans Machine Learning Molecular Structure Structure-Activity Relationship Support Vector Machine
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