AIMC Topic: Huntingtin Protein
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Intersecting impact of CAG repeat and huntingtin knockout in stem cell-derived cortical neurons.
Neurobiology of disease
Apr 19, 2025
Huntington's Disease (HD) is caused by a CAG repeat expansion in the gene encoding huntingtin (HTT). While normal HTT function appears impacted by the mutation, the specific pathways unique to CAG repeat expansion versus loss of normal function are u...
Label-free identification of protein aggregates using deep learning.
Nature communications
Nov 28, 2023
Protein misfolding and aggregation play central roles in the pathogenesis of various neurodegenerative diseases (NDDs), including Huntington's disease, which is caused by a genetic mutation in exon 1 of the Huntingtin protein (Httex1). The fluorescen...
Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington's disease mice.
BMC bioinformatics
Feb 24, 2020
BACKGROUND: MicroRNA (miRNA) regulation is associated with several diseases, including neurodegenerative diseases. Several approaches can be used for modeling miRNA regulation. However, their precision may be limited for analyzing multidimensional da...
CAMELOT: A machine learning approach for coarse-grained simulations of aggregation of block-copolymeric protein sequences.
The Journal of chemical physics
Dec 28, 2015
We report the development and deployment of a coarse-graining method that is well suited for computer simulations of aggregation and phase separation of protein sequences with block-copolymeric architectures. Our algorithm, named CAMELOT for Coarse-g...
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