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Gene Knock-In Techniques

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Prospective identification of hematopoietic lineage choice by deep learning.

Nature methods
Differentiation alters molecular properties of stem and progenitor cells, leading to changes in their shape and movement characteristics. We present a deep neural network that prospectively predicts lineage choice in differentiating primary hematopoi...

Deep learning image recognition enables efficient genome editing in zebrafish by automated injections.

PloS one
One of the most popular techniques in zebrafish research is microinjection. This is a rapid and efficient way to genetically manipulate early developing embryos, and to introduce microbes, chemical compounds, nanoparticles or tracers at larval stages...

Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington's disease mice.

BMC bioinformatics
BACKGROUND: MicroRNA (miRNA) regulation is associated with several diseases, including neurodegenerative diseases. Several approaches can be used for modeling miRNA regulation. However, their precision may be limited for analyzing multidimensional da...