AIMC Topic: Molecular Medicine

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Frustration in physiology and molecular medicine.

Molecular aspects of medicine
Molecules provide the ultimate language in terms of which physiology and pathology must be understood. Myriads of proteins participate in elaborate networks of interactions and perform chemical activities coordinating the life of cells. To perform th...

The impact and future of artificial intelligence in medical genetics and molecular medicine: an ongoing revolution.

Functional & integrative genomics
Artificial intelligence (AI) platforms have emerged as pivotal tools in genetics and molecular medicine, as in many other fields. The growth in patient data, identification of new diseases and phenotypes, discovery of new intracellular pathways, avai...

Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics.

Nature communications
Characterizing the human leukocyte antigen (HLA) bound ligandome by mass spectrometry (MS) holds great promise for developing vaccines and drugs for immune-oncology. Still, the identification of non-tryptic peptides presents substantial computational...