Precision medicine chooses the optimal drug for a patient by considering individual differences. With the tremendous amount of data accumulated for cancers, we develop an interpretable neural network to predict cancer patient survival based on drug p...
Immunotherapy showed remarkable efficacy in several cancer types. However, the majority of patients do not benefit from immunotherapy. Evaluating tumor heterogeneity and immune status before treatment is key to identifying patients that are more like...
Computer methods and programs in biomedicine
Jul 12, 2023
BACKGROUND AND OBJECTIVE: Generalizable and trustworthy deep learning models for PET/CT image segmentation necessitates large diverse multi-institutional datasets. However, legal, ethical, and patient privacy issues challenge sharing of datasets betw...
BACKGROUND: P4 medicine (predict, prevent, personalize, and participate) is a new approach to diagnosing and predicting diseases on a patient-by-patient basis. For the prevention and treatment of diseases, prediction plays a fundamental role. One of ...
Cancer drug response prediction based on genomic information plays a crucial role in modern pharmacogenomics, enabling individualized therapy. Given the expensive and complexity of biological experiments, computational methods serve as effective tool...
OBJECTIVE: Deep neural network (DNN) techniques have demonstrated significant advantages over regression and some other techniques. In recent studies, DNN-based analysis has been conducted on data with high-dimensional input such as omics measurement...
This study aimed to evaluate the performance of traditional-deep learning combination model based on Doppler ultrasound for diagnosing malignant complex cystic and solid breast nodules. A conventional statistical prediction model based on the ultraso...
International journal of biological sciences
Jun 26, 2023
Targeted therapies in cancer treatment can improve efficacy and reduce adverse effects by altering the tissue exposure of specific biomolecules. However, there are still large number of target proteins in cancer are still undruggable, owing to the f...
Computer methods in biomechanics and biomedical engineering
Jun 23, 2023
In this article, we analyze the dynamics of the non-linear tumor-immune delayed (TID) model illustrating the interaction among tumor cells and the immune system (cytotoxic T lymphocytes, T helper cells), where the delays portray the times required fo...
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