Neural networks : the official journal of the International Neural Network Society
Feb 16, 2023
Combinatorial optimization problems such as Traveling Salesman Problem (TSP) have a wide range of real-world applications in transportation, logistics, manufacturing. It has always been a difficult problem to solve large-scale TSP problems quickly be...
The journal of physical chemistry letters
Feb 16, 2023
Predicting protein-ligand binding affinities (PLAs) is a core problem in drug discovery. Recent advances have shown great potential in applying machine learning (ML) for PLA prediction. However, most of them omit the 3D structures of complexes and ph...
Single-cell RNA sequencing (scRNA-seq) data scale surges with high-throughput sequencing technology development. However, although single-cell data analysis is a powerful tool, various issues have been reported, such as sequencing sparsity and comple...
PURPOSE OR OBJECTIVE: Chemical and physical stabilities are two key features considered in pharmaceutical development. Chemical stability is typically reported as a combination of potency and degradation product. Moreover, fluorescent reporter Thiofl...
Oxygen uptake (V˙O2) is an important metric in any exercise test including walking and running. It can be measured using portable spirometers or metabolic analyzers. Those devices are, however, not suitable for constant use by consumers due to their ...
Single-cell data analysis has been at forefront of development in biology and medicine since sequencing data have been made available. An important challenge in single-cell data analysis is the identification of cell types. Several methods have been ...
Sequence alignment is an essential component of bioinformatics, for identifying regions of similarity that may indicate functional, structural, or evolutionary relationships between the sequences. Genome-based diagnostics relying on DNA sequencing ha...
The objective of this study is to explore new imaging techniques with the use of the deep learning method for the identification of cardiac abnormalities present in electrocardiogram (ECG) signals with 2, 3, 4, 6 and 12-lead in the framework of the P...
SIGNIFICANCE: X-ray Cherenkov-luminescence tomography (XCLT) produces fast emission data from megavoltage (MV) x-ray scanning, in which the excitation location of molecules within tissue is reconstructed. However standard filtered backprojection (FBP...
Mechanical cues such as stresses and strains are now recognized as essential regulators in many biological processes like cell division, gene expression or morphogenesis. Studying the interplay between these mechanical cues and biological responses r...
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