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Expert opinion on drug metabolism & toxicology
Oct 27, 2023
INTRODUCTION: Although significant development has been made in high-throughput screening of oral drug absorption and oral bioavailability, prediction continues to play an important role in prediction of oral bioavailability and assisting in the pro...
European journal of drug metabolism and pharmacokinetics
Oct 21, 2023
BACKGROUND AND OBJECTIVE: The biopharmaceutics drug disposition classification system (BDDCS) categorizes drugs into four classes on the basis of their solubility and metabolism. This framework allows for the study of the pharmacokinetics of transpor...
Clinical pharmacology and therapeutics
Sep 29, 2023
The application of machine learning (ML) has shown promising results in precision medicine due to its exceptional performance in dealing with complex multidimensional data. However, using ML for individualized dosing of medicines is still in its earl...
Methods (San Diego, Calif.)
Sep 29, 2023
Artificial intelligence (AI), particularly deep learning as a subcategory of AI, provides opportunities to accelerate and improve the process of discovering and developing new drugs. The use of AI in drug discovery is still in its early stages, but i...
Drug discovery today
Sep 7, 2023
Pharmaceutical co-crystals represent a growing class of crystal forms in the context of pharmaceutical science. They are attractive to pharmaceutical scientists because they significantly expand the number of crystal forms that exist for an active ph...
Applied microbiology and biotechnology
Aug 24, 2023
Enzymes have promising applications in chemicals, food, pharmaceuticals, and other variety products because of their high efficiency, specificity, and environmentally friendly properties. However, due to the complexity of raw materials, pH, temperatu...
Journal of chemical information and modeling
Aug 21, 2023
In the drug discovery paradigm, the evaluation of absorption, distribution, metabolism, and excretion (ADME) and toxicity properties of new chemical entities is one of the most critical issues, which is a time-consuming process, immensely expensive, ...
Drug development research
Aug 17, 2023
Animal testing is required in drug development research and is crucial for assessing the efficacy and safety of medications before they are commercialized. However, the newly furnished Food and Drug Administration Modernization Act 2.0 has given new ...
Scientific reports
Aug 7, 2023
Pharmaceutical companies operate in a strictly regulated and highly risky environment in which a single slip can lead to serious financial implications. Accordingly, the announcements of clinical trial results tend to determine the future course of e...
Expert opinion on drug discovery
Aug 1, 2023
INTRODUCTION: Low metabolic clearance is usually a highly desirable property of drug candidates in order to reduce dose and dosing frequency. However, measurement of low clearance can be challenging in drug discovery. A number of new tools have recen...