Phosphatidylglycerols

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Lipid discovery enabled by sequence statistics and machine learning.

eLife Dec 10, 2024
Bacterial membranes are complex and dynamic, arising from an array of evolutionary pressures. One enzyme that alters membrane compositions through covalent lipid modification is MprF. We recently identified that MprF synthesizes lysyl-phosphatidylgl...
Machine Learning Bacterial Proteins Streptococcus agalactiae Glycolipids Lysine Enterococcus Phosphatidylglycerols Substrate Specificity
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Design and synthesis of cell selective α/β-diastereomeric peptidomimetic with potent in vivo antibacterial activity against methicillin resistant S. Aureus.

Bioorganic chemistry Dec 26, 2017
Design of therapeutically viable antimicrobial peptides with cell selectivity against microorganisms is an important step towards the development of new antimicrobial agents. Here, we report four de novo designed, short amphipathic sequences based on...
Humans Anti-Bacterial Agents Female Animals Microbial Sensitivity Tests Escherichia coli Methicillin-Resistant Staphylococcus aureus Mice, Inbred BALB C Amino Acid Sequence Pseudomonas aeruginosa Keratinocytes Enterococcus faecalis Phosphatidylcholines Erythrocytes Acinetobacter baumannii Hemolysis Lipid Bilayers Peptidomimetics Phosphatidylglycerols Stereoisomerism
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