AIMC Topic: Phosphatidylcholines

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Unsupervised Machine Learning for Analysis of Phase Separation in Ternary Lipid Mixture.

Journal of chemical theory and computation Oct 7, 2019
Phase separation in mixed lipid systems has been extensively studied both experimentally and theoretically because of its biological importance. A detailed description of such complex systems undoubtedly requires novel mathematical frameworks that ar...
Molecular Dynamics Simulation Phosphatidylcholines 1,2-Dipalmitoylphosphatidylcholine Lipid Bilayers Unsupervised Machine Learning Lipids Cholesterol
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Design and synthesis of cell selective α/β-diastereomeric peptidomimetic with potent in vivo antibacterial activity against methicillin resistant S. Aureus.

Bioorganic chemistry Dec 26, 2017
Design of therapeutically viable antimicrobial peptides with cell selectivity against microorganisms is an important step towards the development of new antimicrobial agents. Here, we report four de novo designed, short amphipathic sequences based on...
Phosphatidylcholines Erythrocytes Keratinocytes Enterococcus faecalis Lipid Bilayers Peptidomimetics Phosphatidylglycerols Acinetobacter baumannii Hemolysis Methicillin-Resistant Staphylococcus aureus Mice, Inbred BALB C Amino Acid Sequence Pseudomonas aeruginosa Microbial Sensitivity Tests Escherichia coli Female Animals Stereoisomerism Humans Anti-Bacterial Agents
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Improving the accuracy and convergence of drug permeation simulations via machine-learned collective variables.

The Journal of chemical physics Jul 28, 2021
Understanding the permeation of biomolecules through cellular membranes is critical for many biotechnological applications, including targeted drug delivery, pathogen detection, and the development of new antibiotics. To this end, computer simulation...
Cholesterol Molecular Dynamics Simulation Algorithms Trimethoprim Unsupervised Machine Learning Phosphatidylcholines Lipid Bilayers Pharmacokinetics Thermodynamics
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Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/ bile salt bilosomes.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
Although ebastine (EBT) can impede histamine-induced skin allergic reaction and persuade long acting selective H1 receptor antagonistic effects but its poor water solubility circumscribed its clinical application. The main objective of this research ...
Histamine H1 Antagonists Liposomes Phosphatidylcholines Solubility Biological Availability Drug Liberation Piperidines Butyrophenones Nanoparticles Bile Acids and Salts Drug Compounding Administration, Oral
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ACTIVITY OF BLACKCURRANT AND CHOKEBERRY EXTRACTS AND TWO MAJOR CYANIDIN GLYCOSIDES AGAINST LIPID MEMBRANE OXIDATION AND THEIR BINDING PROPERTIES TO ALBUMIN.

Acta poloniae pharmaceutica Mar 1, 2017
The purpose of this study was to explain how extracts from chokeberry and blackcurrant interact with the lipid phase of biological membrane and with human albumin - the main protein of blood. Aiming at better understanding of the observed biological ...
Fruit Plants, Medicinal Liposomes Protein Binding Humans Oxidation-Reduction Phosphatidylcholines Galactosides Antioxidants Time Factors Anthocyanins Serum Albumin, Human Membrane Fluidity Prunus Plant Extracts Ribes Phytotherapy Cell Membrane Dose-Response Relationship, Drug
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