AIMC Topic: Quinolines

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Label-free detection of histone based on cationic conjugated polymer-mediated fluorescence resonance energy transfer.

Talanta Dec 5, 2017
A simple and homogeneous histone assay is developed based on histone-induced DNA compressing coupled with cationic conjugated polymer (CCP)-mediated fluorescence resonance energy transfer (FRET). In this strategy, the CCP serves as the FRET donor and...
Humans Animals Cattle Organic Chemicals DNA Limit of Detection Fluorescent Dyes HeLa Cells Fluorescence Resonance Energy Transfer Benzothiazoles Static Electricity Quinolines Cations Diamines Histones Polyethylenes
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Syntheses and antibacterial activity of soluble 9-bromo substituted indolizinoquinoline-5,12-dione derivatives.

European journal of medicinal chemistry Dec 27, 2016
In our previous research, 9-bromo indolizinoquinoline-5,12-dione 1 has been found to be a good anti-MRSA agent. However, it had very low bioavailability in vivo possibly due to its low solubility in water. In order to obtain the derivatives with high...
Humans Anti-Bacterial Agents Microbial Sensitivity Tests Water Bacteria Solubility Quinolines Chemistry Techniques, Synthetic
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Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives.

Bioorganic & medicinal chemistry letters Jun 16, 2016
The present study describes the synthesis of two new series of 3-hydroxy-N-(4-oxo-2-phenyl-1,3-thiazinan-3-yl)-8-(trifluoromethyl)quinoline-2-carboxamide derivatives (4a-j) and 3-((7-chloroquinolin-4-ylamino)methyl)-2-phenyl-1,3-thiazinan-4-one deriv...
Anti-Bacterial Agents Microbial Sensitivity Tests Spectroscopy, Fourier Transform Infrared Structure-Activity Relationship Plasmodium falciparum Antitubercular Agents Antimalarials Mycobacterium tuberculosis Gram-Negative Bacteria Quinolines Magnetic Resonance Spectroscopy Clostridium tetani Thiazines
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PathSynergy: a deep learning model for predicting drug synergy in liver cancer.

Briefings in bioinformatics Mar 4, 2025
Cancer is a major public health problem while liver cancer is the main cause of global cancer-related deaths. The previous study demonstrates that the 5-year survival rate for advanced liver cancer is only 30%. Few of the first-line targeted drugs in...
Humans Antineoplastic Agents Deep Learning Liver Neoplasms Drug Synergism Phenylurea Compounds Quinolines Sorafenib
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