AIMC Topic: Receptor, Metabotropic Glutamate 5

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Epitope Identification of an mGlu5 Receptor Nanobody Using Physics-Based Molecular Modeling and Deep Learning Techniques.

Journal of chemical information and modeling Feb 29, 2024
The world has witnessed a revolution in therapeutics with the development of biological medicines such as antibodies and antibody fragments, notably nanobodies. These nanobodies possess unique characteristics including high specificity and modulatory...
Animals Deep Learning Rats Models, Molecular Epitopes Molecular Dynamics Simulation Protein Conformation Single-Domain Antibodies Receptor, Metabotropic Glutamate 5 Epitope Mapping
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Profiling prediction of nuclear receptor modulators with multi-task deep learning methods: toward the virtual screening.

Briefings in bioinformatics Sep 20, 2022
Nuclear receptors (NRs) are ligand-activated transcription factors, which constitute one of the most important targets for drug discovery. Current computational strategies mainly focus on a single target, and the transfer of learned knowledge among N...
Deep Learning Receptors, Calcitriol Receptors, Aryl Hydrocarbon Receptors, Muscarinic Ligands Receptors, Cytoplasmic and Nuclear Receptor, Metabotropic Glutamate 5 Receptors, Artificial Proto-Oncogene Proteins c-met B-Cell Activation Factor Receptor Calcitonin Receptor-Like Protein Cytokine Receptor gp130 Histamine H2 Antagonists Neurokinin-1 Receptor Antagonists Receptor-Like Protein Tyrosine Phosphatases, Class 2 Receptors, Gastrointestinal Hormone Receptors, Polymeric Immunoglobulin
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Analysis of Drug Design for a Selection of G Protein-Coupled Neuro- Receptors Using Neural Network Techniques.

Current computer-aided drug design Jan 1, 2015
A study is presented on how well possible drug-molecules can be predicted with respect to their function and binding to a selection of neuro-receptors by the use of artificial neural networks. The ligands investigated in this study are chosen to be c...
Humans Neural Networks, Computer Drug Design Protein Binding Ligands Receptor, Metabotropic Glutamate 5 Receptor, Serotonin, 5-HT2B Receptors, Opioid, mu
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