AIMC Topic: Receptors, Calcitriol

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Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis.

Frontiers in cellular and infection microbiology Jan 8, 2025
BACKGROUND: The vitamin D pathway contributes to the microbicidal activity of macrophages against infection. In addition to induction of this pathway, interferon-gamma (IFNγ), interleukin (IL)-15, and IL32γ are part of a network of pro-inflammatory ...
25-Hydroxyvitamin D3 1-alpha-Hydroxylase Receptors, Calcitriol Vitamin D Leishmaniasis, Cutaneous Female Humans Young Adult Cytokines Male Adult Polymorphism, Single Nucleotide Middle Aged Genotype Genetic Predisposition to Disease Treatment Outcome
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Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population.

The British journal of oral & maxillofacial surgery Aug 28, 2020
Vitamin D (VD) levels and several variants in the vitamin D receptor (VDR) gene are associated with the occurrence of diseases of the bones and cartilage. The aim of this research was to study and compare the association of the BsmI variant in the VD...
Alleles Vitamin D Case-Control Studies Humans Receptors, Calcitriol Genetic Predisposition to Disease Temporomandibular Joint Disorders Genotype
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Serum vitamin D deficiency and vitamin D receptor gene polymorphism are associated with increased risk of cardiovascular disease in a Chinese rural population.

Nutrition research (New York, N.Y.) Sep 13, 2018
Several studies have reported a conflicting association between vitamin D deficiency, vitamin D receptor (VDR) polymorphism, and the risk of cardiovascular disease (CVD). We hypothesized that serum 25(OH)D concentrations and single nucleotide polymor...
Adult Male Cardiovascular Diseases Middle Aged China Blood Glucose Biomarkers Female Vitamin D Deficiency Aged Alleles Rural Population Humans Asian People Haplotypes Vitamin D Polymorphism, Single Nucleotide Receptors, Calcitriol Gene Frequency Genotype Triglycerides Logistic Models
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Machine learning approaches infer vitamin D signaling: Critical impact of vitamin D receptor binding within topologically associated domains.

The Journal of steroid biochemistry and molecular biology Jul 22, 2018
The vitamin D-modulated transcriptome of highly responsive human cells, such as THP-1 monocytes, comprises more than 500 genes, half of which are primary targets. Recently, we proposed a chromatin model of vitamin D signaling demonstrating that nearl...
CCCTC-Binding Factor Gene Expression Regulation Chromatin Signal Transduction Vitamin D Receptors, Calcitriol Cell Line THP-1 Cells High-Throughput Nucleotide Sequencing Humans Algorithms Machine Learning Protein Binding RNA, Messenger
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Influence of vitamin D and calcium-sensing receptor gene variants on calcium metabolism in end-stage renal disease: insights from machine learning analysis.

European review for medical and pharmacological sciences Nov 1, 2024
OBJECTIVE: End-stage renal disease (ESRD) commonly manifests with disrupted calcium balance, leading to renal osteodystrophy. We posited that variations in the genetic makeup of vitamin D and calcium-sensing receptors, specifically single nucleotide ...
Cross-Sectional Studies Male Middle Aged Female Aged Adult Kidney Failure, Chronic Calcium Receptors, Calcium-Sensing Polymorphism, Single Nucleotide Humans Vitamin D Machine Learning Receptors, Calcitriol
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Profiling prediction of nuclear receptor modulators with multi-task deep learning methods: toward the virtual screening.

Briefings in bioinformatics Sep 20, 2022
Nuclear receptors (NRs) are ligand-activated transcription factors, which constitute one of the most important targets for drug discovery. Current computational strategies mainly focus on a single target, and the transfer of learned knowledge among N...
Deep Learning Receptors, Calcitriol Receptors, Cytoplasmic and Nuclear Receptor, Metabotropic Glutamate 5 Receptors, Artificial Receptors, Aryl Hydrocarbon Receptors, Muscarinic Ligands Neurokinin-1 Receptor Antagonists Receptor-Like Protein Tyrosine Phosphatases, Class 2 Receptors, Gastrointestinal Hormone Receptors, Polymeric Immunoglobulin Calcitonin Receptor-Like Protein Cytokine Receptor gp130 Proto-Oncogene Proteins c-met Histamine H2 Antagonists B-Cell Activation Factor Receptor
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