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Receptors, Calcitriol

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Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis.

Frontiers in cellular and infection microbiology 39844838
BACKGROUND: The vitamin D pathway contributes to the microbicidal activity of macrophages against infection. In addition to induction of this pathway, interferon-gamma (IFNγ), interleukin (IL)-15, and IL32γ are part of a network of pro-inflammatory ...
25-Hydroxyvitamin D3 1-alpha-Hydroxylase Adult Cytokines Female Genetic Predisposition to Disease Genotype Humans Leishmaniasis, Cutaneous Male Middle Aged Polymorphism, Single Nucleotide Receptors, Calcitriol Treatment Outcome Vitamin D Young Adult
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Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population.

The British journal of oral & maxillofacial surgery 33863594
Vitamin D (VD) levels and several variants in the vitamin D receptor (VDR) gene are associated with the occurrence of diseases of the bones and cartilage. The aim of this research was to study and compare the association of the BsmI variant in the VD...
Alleles Case-Control Studies Genetic Predisposition to Disease Genotype Humans Receptors, Calcitriol Temporomandibular Joint Disorders Vitamin D
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Serum vitamin D deficiency and vitamin D receptor gene polymorphism are associated with increased risk of cardiovascular disease in a Chinese rural population.

Nutrition research (New York, N.Y.) 30683435
Several studies have reported a conflicting association between vitamin D deficiency, vitamin D receptor (VDR) polymorphism, and the risk of cardiovascular disease (CVD). We hypothesized that serum 25(OH)D concentrations and single nucleotide polymor...
Adult Aged Alleles Asian People Biomarkers Blood Glucose Cardiovascular Diseases China Female Gene Frequency Genotype Haplotypes Humans Logistic Models Male Middle Aged Polymorphism, Single Nucleotide Receptors, Calcitriol Rural Population Triglycerides Vitamin D Vitamin D Deficiency
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Machine learning approaches infer vitamin D signaling: Critical impact of vitamin D receptor binding within topologically associated domains.

The Journal of steroid biochemistry and molecular biology 30044963
The vitamin D-modulated transcriptome of highly responsive human cells, such as THP-1 monocytes, comprises more than 500 genes, half of which are primary targets. Recently, we proposed a chromatin model of vitamin D signaling demonstrating that nearl...
Algorithms CCCTC-Binding Factor Cell Line Chromatin Gene Expression Regulation High-Throughput Nucleotide Sequencing Humans Machine Learning Protein Binding Receptors, Calcitriol RNA, Messenger Signal Transduction THP-1 Cells Vitamin D
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Profiling prediction of nuclear receptor modulators with multi-task deep learning methods: toward the virtual screening.

Briefings in bioinformatics 35998896
Nuclear receptors (NRs) are ligand-activated transcription factors, which constitute one of the most important targets for drug discovery. Current computational strategies mainly focus on a single target, and the transfer of learned knowledge among N...
B-Cell Activation Factor Receptor Calcitonin Receptor-Like Protein Cytokine Receptor gp130 Deep Learning Histamine H2 Antagonists Ligands Neurokinin-1 Receptor Antagonists Proto-Oncogene Proteins c-met Receptor-Like Protein Tyrosine Phosphatases, Class 2 Receptor, Metabotropic Glutamate 5 Receptors, Artificial Receptors, Aryl Hydrocarbon Receptors, Calcitriol Receptors, Cytoplasmic and Nuclear Receptors, Gastrointestinal Hormone Receptors, Muscarinic Receptors, Polymeric Immunoglobulin
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Influence of vitamin D and calcium-sensing receptor gene variants on calcium metabolism in end-stage renal disease: insights from machine learning analysis.

European review for medical and pharmacological sciences 39624014
OBJECTIVE: End-stage renal disease (ESRD) commonly manifests with disrupted calcium balance, leading to renal osteodystrophy. We posited that variations in the genetic makeup of vitamin D and calcium-sensing receptors, specifically single nucleotide ...
Adult Aged Calcium Cross-Sectional Studies Female Humans Kidney Failure, Chronic Machine Learning Male Middle Aged Polymorphism, Single Nucleotide Receptors, Calcitriol Receptors, Calcium-Sensing Vitamin D
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