T-bet Transcription Factor

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Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature.

eLife May 14, 2020
The transcriptional activation and repression during NK cell ontology are poorly understood. Here, using single-cell RNA-sequencing, we reveal a novel role for T-bet in suppressing the immature gene signature during murine NK cell development. Based ...
Machine Learning Phenotype Animals Gene Expression Profiling Transcriptome Single-Cell Analysis RNA-Seq Genotype Cluster Analysis Mice, Inbred C57BL Mice, Knockout Proto-Oncogene Proteins c-akt Bone Marrow Cells Gene Expression Regulation Killer Cells, Natural Forkhead Box Protein O1 Mechanistic Target of Rapamycin Complex 2 Rapamycin-Insensitive Companion of mTOR Protein Regulatory-Associated Protein of mTOR T-Box Domain Proteins T-bet Transcription Factor
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