T-Box Domain Proteins

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AI-assisted identification of innovative phytochemicals from Aizoon canariense aimed at brachyury protein in chordoma: a computational strategy.

Scientific reports Dec 19, 2025
Chordoma is an unique and aggressive bone malignancy along with limited therapeutic options, largely due to the undruggable nature of the TBXT oncoprotein. In this study, we employed an AI-assisted drug discovery approach to optimize β-sitosterol fro...
Humans Artificial Intelligence Animals Drug Discovery Phytochemicals Molecular Dynamics Simulation Sitosterols Chordoma T-Box Domain Proteins Fetal Proteins Brachyury Protein
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Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature.

eLife May 14, 2020
The transcriptional activation and repression during NK cell ontology are poorly understood. Here, using single-cell RNA-sequencing, we reveal a novel role for T-bet in suppressing the immature gene signature during murine NK cell development. Based ...
Machine Learning Phenotype Animals Gene Expression Profiling Transcriptome Single-Cell Analysis RNA-Seq Genotype Cluster Analysis Mice, Inbred C57BL Mice, Knockout Proto-Oncogene Proteins c-akt Bone Marrow Cells Gene Expression Regulation Killer Cells, Natural Forkhead Box Protein O1 Mechanistic Target of Rapamycin Complex 2 Rapamycin-Insensitive Companion of mTOR Protein Regulatory-Associated Protein of mTOR T-Box Domain Proteins T-bet Transcription Factor
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