AIMC Topic: Toll-Like Receptor 7

Clear Filters Showing 1 to 3 of 3 articles

Artificial intelligence-driven discovery of novel scaffolds for selective TLR7 antagonists and their application in enhancing mRNA translation efficiency.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jun 20, 2025
Toll-like receptor 7 (TLR7) is crucial in the innate immune response, responsible for recognizing single-stranded RNA from external pathogens and initiating the production of inflammatory cytokines and type I interferons. Despite the potential therap...
Humans Artificial Intelligence Molecular Docking Simulation Drug Discovery RNA, Messenger Toll-Like Receptor 7 HEK293 Cells Protein Biosynthesis Toll-Like Receptor 8
View on PubMed DOI

Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JNJ-64794964, a TLR-7 agonist, in healthy adults.

Antiviral therapy Oct 27, 2021
BACKGROUND: This Phase I, two-part, first-in-human study assessed safety/tolerability and pharmacokinetics/pharmacodynamics of single-ascending doses (SAD) and multiple doses (MD) of the oral toll-like receptor-7 agonist, JNJ-64794964 (JNJ-4964) in h...
Humans Cytokines Adult Area Under Curve Double-Blind Method Adjuvants, Immunologic Interferon-alpha Toll-Like Receptor 7
View on PubMed DOI

Structure-aware machine learning identifies microRNAs operating as Toll-like receptor 7/8 ligands.

RNA biology Jul 9, 2021
MicroRNAs (miRNAs) can serve as activation signals for membrane receptors, a recently discovered function that is independent of the miRNAs' conventional role in post-transcriptional gene regulation. Here, we introduce a machine learning approach, Br...
Humans Machine Learning Animals Mice Mice, Inbred C57BL MicroRNAs Microglia Oligonucleotides Toll-Like Receptor 7 Ligands Gene Expression Regulation Toll-Like Receptor 8
View on PubMed DOI
Popular Topics
Recent Journals