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Transcription Elongation, Genetic

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A machine learning-based framework for modeling transcription elongation.

Proceedings of the National Academy of Sciences of the United States of America 33526657
RNA polymerase II (Pol II) generally pauses at certain positions along gene bodies, thereby interrupting the transcription elongation process, which is often coupled with various important biological functions, such as precursor mRNA splicing and gen...
Base Sequence Binding Sites DNA Methylation Epigenesis, Genetic Genome, Human HEK293 Cells HeLa Cells Histones Humans Machine Learning Models, Biological Nucleotide Motifs Protein Processing, Post-Translational RNA Polymerase II RNA Splice Sites RNA Splicing Transcription Elongation, Genetic
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Probabilistic and machine-learning methods for predicting local rates of transcription elongation from nascent RNA sequencing data.

Nucleic acids research 39964478
Rates of transcription elongation vary within and across eukaryotic gene bodies. Here, we introduce new methods for predicting elongation rates from nascent RNA sequencing data. First, we devise a probabilistic model that predicts nucleotide-specific...
Binding Sites CCCTC-Binding Factor DNA Methylation Epigenomics Histone Code Histones Humans Machine Learning Models, Statistical Neural Networks, Computer RNA Splice Sites Sequence Analysis, RNA Transcription Elongation, Genetic
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