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Early response to SPN-812 (viloxazine extended-release) can predict efficacy outcome in pediatric subjects with ADHD: a machine learning post-hoc analysis of four randomized clinical trials.

Psychiatry research 33418457
Machine learning (ML) was used to determine whether early response can predict efficacy outcome in pediatric subjects with ADHD treated with SPN-812. We used data from four Phase 3 placebo-controlled trials of 100- to 600-mg/day SPN-812 (N=1397; 6-17...
Adolescent Attention Deficit Disorder with Hyperactivity Body Mass Index Body Weight Central Nervous System Stimulants Child Clinical Trials as Topic Delayed-Action Preparations Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Humans Machine Learning Male Randomized Controlled Trials as Topic Treatment Outcome Viloxazine
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