Showing 261 to 270 of 837 articles
Clear Filters
Bioinformatics (Oxford, England)
May 4, 2023
MOTIVATION: As an important group of proteins discovered in phages, anti-CRISPR inhibits the activity of the immune system of bacteria (i.e. CRISPR-Cas), offering promise for gene editing and phage therapy. However, the prediction and discovery of an...
Bioinformatics (Oxford, England)
May 4, 2023
MOTIVATION: Liquid chromatography coupled with high-resolution mass spectrometry is widely used in composition profiling in untargeted metabolomics research. While retaining complete sample information, mass spectrometry (MS) data naturally have the ...
Bioinformatics (Oxford, England)
Apr 3, 2023
UNLABELLED: The DynaSig-ML ('Dynamical Signatures-Machine Learning') Python package allows the efficient, user-friendly exploration of 3D dynamics-function relationships in biomolecules, using datasets of experimental measures from large numbers of s...
Bioinformatics (Oxford, England)
Apr 3, 2023
MOTIVATION: Identifying the B-cell epitopes is an essential step for guiding rational vaccine development and immunotherapies. Since experimental approaches are expensive and time-consuming, many computational methods have been designed to assist B-c...
Bioinformatics (Oxford, England)
Apr 3, 2023
MOTIVATION: Combination therapies have emerged as a treatment strategy for cancers to reduce the probability of drug resistance and to improve outcomes. Large databases curating the results of many drug screening studies on preclinical cancer cell li...
Bioinformatics (Oxford, England)
Apr 3, 2023
MOTIVATION: Relation extraction (RE) is a crucial process to deal with the amount of text published daily, e.g. to find missing associations in a database. RE is a text mining task for which the state-of-the-art approaches use bidirectional encoders,...
Bioinformatics (Oxford, England)
Apr 3, 2023
MOTIVATION: Human traits are typically represented in both the biomedical literature and large population studies as descriptive text strings. Whilst a number of ontologies exist, none of these perfectly represent the entire human phenome and exposom...
Bioinformatics (Oxford, England)
Apr 3, 2023
MOTIVATION: Therapeutic peptides play an important role in immune regulation. Recently various therapeutic peptides have been used in the field of medical research, and have great potential in the design of therapeutic schedules. Therefore, it is ess...
Bioinformatics (Oxford, England)
Apr 3, 2023
MOTIVATION: This article describes NEREL-BIO-an annotation scheme and corpus of PubMed abstracts in Russian and smaller number of abstracts in English. NEREL-BIO extends the general domain dataset NEREL by introducing domain-specific entity types. NE...
Bioinformatics (Oxford, England)
Apr 3, 2023
MOTIVATION: Generating molecules of high quality and drug-likeness in the vast chemical space is a big challenge in the drug discovery. Most existing molecule generative methods focus on diversity and novelty of molecules, but ignoring drug potential...