BACKGROUND: Heat stress (HS) is a significant challenge in poultry, negatively impacting feed efficiency and survival. These adaptive responses could lead to disrupted lipid metabolism, impaired immunity, and neural damage. We hypothesized that the n... read more
Classification of Indo-Pacific whiting (Sillago sihama) from three coastal regions of Vietnam revealed distinct population structures using otolith morphology. All three analytical approaches - traditional morphometrics using basic dimensional parame... read more
Spatially resolved transcriptomics (SRT) for characterizing spatial cellular heterogeneities in tissue environments requires systematic analytical approaches to elucidate gene expression variations within their physiological context. Here, we introdu... read more
ChatGPT gained widespread attention for its capabilities in natural language processing, enabling machines to assess human language inputs and generate complex, yet evolving answers. As large language models (LLMs) continue to develop, clear guidelin... read more
BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder driven by complex, incompletely understood genetic and pathogenic factors. E3 ubiquitin ligases (E3s), crucial for protein degradation, are implicated in AD, but their spe... read more
Angewandte Chemie (International ed. in English)
Jul 29, 2025
Derivatization-enhanced multidimensional metabolomics combined with ion mobility mass spectrometry will greatly improve the accuracy and coverage of metabolic analysis. However, accurate prediction of the large-scale collision cross section (CCS) of ... read more
Methods for automatic chemical retrosynthesis have found recent success through the application of models traditionally built for natural language processing, primarily through transformer neural networks. These models have demonstrated significant a... read more
Journal of chemical theory and computation
Jul 29, 2025
This study employed an artificial intelligence-enhanced molecular simulation framework to enable efficient path integral molecular dynamics (PIMD) simulations. Owing to its modular architecture and high-throughput capabilities, the framework effectiv... read more
Journal of chemical information and modeling
Jul 29, 2025
Drug discovery is a lengthy and resource-intensive process that requires innovative computational techniques to expedite the transition from laboratory research to life-saving medications. Here, we introduce Qsarna, a comprehensive online platform th... read more
BACKGROUND: The exploration of drug-target interactions (DTIs) is a critical step in drug discovery and drug repurposing. Recently, network-based methods have emerged as a prominent research area for predicting DTIs. These methods excel by extracting... read more
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