Mitochondria play a key role in energy production and metabolism, making them a promising target for metabolic engineering and disease treatment. However, despite the known influence of passenger proteins on localization efficiency, only a few protei...
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
40257873
Exploring the pathogenic mechanisms of brain disorders within population is an important research in the field of neuroscience. Existing methods either combine clinical information to assist analysis or use data augmentation for sample expansion, ign...
Single-cell multi-omics technologies have revolutionized the study of cell states and functions by simultaneously profiling multiple molecular layers within individual cells. However, existing methods for integrating these data struggle to preserve c...
With the rapid advances in single-cell sequencing technology, it is now feasible to conduct in-depth genetic analysis in individual cells. Study on the dynamics of single cells in response to perturbations is of great significance for understanding t...
Elucidating the tertiary structure of proteins is important for understanding their functions and interactions. While deep neural networks have advanced the prediction of a protein's native structure from its amino acid sequence, the focus on a singl...
BACKGROUND: Artificial patient technology could transform health care by accelerating diagnosis, treatment, and mapping clinical pathways. Deep learning methods for generating artificial data in health care include data augmentation by variational au...
Designing an ECG sensor circuit requires a comprehensive approach to detect, amplify, filter, and condition the weak electrical signals produced by the heart. To evaluate sensor performance under realistic conditions, diverse ECG signals with embedde...
SIGNIFICANCE: Investigating optical properties (OPs) is crucial in the field of biophotonics, as it has a broad impact on understanding light-tissue interactions. However, current techniques, such as inverse Monte Carlo simulations (IMCS), have limit...
BACKGROUND: Clustering scRNA-seq data plays a vital role in scRNA-seq data analysis and downstream analyses. Many computational methods have been proposed and achieved remarkable results. However, there are several limitations of these methods. First...
Diabetes is a widespread condition that can lead to serious vision problems over time. Timely identification and treatment of diabetic retinopathy (DR) depend on accurately segmenting retinal vessels, which can be achieved through the invasive techni...