Oxidative Phosphorylation Pathway in Ankylosing Spondylitis: Multi-Omics Analysis and Machine Learning.

Journal: International journal of rheumatic diseases
PMID: 40296690

Abstract

INTRODUCTION: Ankylosing spondylitis (AS) is a chronic inflammatory disease affecting the axial skeleton, characterized by immune microenvironment dysregulation and elevated cytokines like TNF-α and IL-17. Mitochondrial oxidative phosphorylation (OXPHOS), crucial for immune cell function and survival, is implicated in AS pathogenesis. This study explores OXPHOS-related mechanisms in AS, identifies key genes using machine learning, and highlights potential therapeutic targets for precision medicine.

Authors

  • Yuling Chen
    Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
  • Yuan Xu
    Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, China.
  • Shuangyan Cao
    Department of Rheumatology and Immunology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
  • Qing Lv
    School of Water Resources and Environment, MOE Key Laboratory of Groundwater Circulation and Environmental Evolution, China University of Geosciences (Beijing), Beijing 100083, PR China.
  • Yuanchun Ye
    School of Science, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
  • Jieruo Gu
    Department of Rheumatology and Immunology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.

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