AIMC Topic: Oxidative Phosphorylation

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Identifying as a Biomarker Covering Multiple Pathogenic Pathways for Diagnosing Heart Failure: From Machine Learning to Mechanism Interpretation.

Biomolecules Feb 2, 2024
BACKGROUND: The pathophysiologic heterogeneity of heart failure (HF) necessitates a more detailed identification of diagnostic biomarkers that can reflect its diverse pathogenic pathways.
Extracellular Matrix Proteins Oxidative Phosphorylation Intercellular Signaling Peptides and Proteins Captopril Machine Learning Biomarkers Molecular Docking Simulation Carrier Proteins Glycoproteins Heart Failure Humans
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Machine learning compensates fold-change method and highlights oxidative phosphorylation in the brain transcriptome of Alzheimer's disease.

Scientific reports Jul 1, 2021
Alzheimer's disease (AD) is a neurodegenerative disorder causing 70% of dementia cases. However, the mechanism of disease development is still elusive. Despite the availability of a wide range of biological data, a comprehensive understanding of AD's...
Alzheimer Disease Oxidative Phosphorylation Brain Transcriptome Humans Machine Learning
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Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data.

PloS one Nov 8, 2019
Several studies have reported mitochondrial dysfunction in rheumatoid arthritis (RA). Many nuclear DNA (nDNA) encoded proteins translocate to mitochondria, but their participation in the dysfunction of this cell organelle during RA is quite unclear. ...
Gene Ontology Humans Apoptosis Gene Expression Profiling Mitochondrial Proteins Reactive Oxygen Species Protein Interaction Maps Arthritis, Rheumatoid Mitochondria Oxidative Phosphorylation Models, Biological Inflammation Gene Expression Regulation Synovial Membrane
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Analysis of differentially expressed genes in rheumatoid arthritis and osteoarthritis by integrated microarray analysis.

Journal of cellular biochemistry Mar 4, 2019
BACKGROUND: Rheumatoid arthritis (RA) and osteoarthritis (OA) were two major types of joint diseases. This study aimed to explore the mechanism underlying OA and RA and analyze their difference by integrated analysis of multiple gene expression data ...
Humans Gene Expression Profiling Protein Interaction Maps Gene Regulatory Networks Arthritis, Rheumatoid Signal Transduction Gene Ontology Oligonucleotide Array Sequence Analysis Oxidative Phosphorylation Gene Expression Regulation Synovial Membrane Inhibitor of Apoptosis Proteins Chemokines Osteoarthritis Ubiquitin-Protein Ligases
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Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning.

Scientific reports Jan 26, 2015
In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and mitochondrial morpho-functional changes. Empirical evidence suggests these aberratio...
Mitochondria Mitochondrial Diseases Fibroblasts Electron Transport Complex I Oxidative Phosphorylation Reactive Oxygen Species Humans Chromans Membrane Potential, Mitochondrial Machine Learning Citrate (si)-Synthase Leigh Disease
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Machine Learning Assisted Stroke Prediction in Mechanical Circulatory Support: Predictive Role of Systemic Mitochondrial Dysfunction.

ASAIO journal (American Society for Artificial Internal Organs : 1992) May 1, 2025
Stroke continues to be a major adverse event in advanced congestive heart failure (CHF) patients after continuous-flow left ventricular assist device (CF-LVAD) implantation. Abnormalities in mitochondrial oxidative phosphorylation (OxPhos) have been ...
Humans Male Middle Aged Stroke Machine Learning Female Aged Heart-Assist Devices Mitochondria Oxidative Phosphorylation Heart Failure
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Oxidative Phosphorylation Pathway in Ankylosing Spondylitis: Multi-Omics Analysis and Machine Learning.

International journal of rheumatic diseases May 1, 2025
INTRODUCTION: Ankylosing spondylitis (AS) is a chronic inflammatory disease affecting the axial skeleton, characterized by immune microenvironment dysregulation and elevated cytokines like TNF-α and IL-17. Mitochondrial oxidative phosphorylation (OXP...
Case-Control Studies Single-Cell Analysis RNA-Seq Machine Learning Gene Expression Profiling Female Transcriptome Adult Male Middle Aged Humans Gene Regulatory Networks Mitochondria Leukocytes, Mononuclear Multiomics Oxidative Phosphorylation Signal Transduction Spondylitis, Ankylosing
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