AIMC Topic: Oxidative Phosphorylation

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Integrative Role of RNA N7-methylguanosine in epilepsy: Regulation of neuronal oxidative phosphorylation, programmed death and immune microenvironment.

PloS one Jul 14, 2025
Epilepsy is a common brain disease that causes different types of seizures, with an incidence rate of nearly 1%. N7-methylguanosine (m7G) is a prevalent RNA modification that has attracted significant attention in recent research. In this study, we i...
Humans Epilepsy Female Guanosine Neurons Oxidative Phosphorylation Male Apoptosis
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GBE1 alleviates MPTP-induced PD symptoms in mice by enhancing glycolysis and oxidative phosphorylation.

Brain research Apr 30, 2025
In Parkinson's disease (PD), the disturbance of energy metabolism due to glucose metabolic reprogramming may be a critical factor contributing to neuronal degeneration and death. Glycolysis, as the core process of glucose metabolism, not only serves ...
PC12 Cells Oxidative Phosphorylation Humans MPTP Poisoning Animals Mice, Inbred C57BL Male Rats Parkinson Disease Disease Models, Animal Mice Corpus Striatum Glycolysis
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Identifying as a Biomarker Covering Multiple Pathogenic Pathways for Diagnosing Heart Failure: From Machine Learning to Mechanism Interpretation.

Biomolecules Feb 2, 2024
BACKGROUND: The pathophysiologic heterogeneity of heart failure (HF) necessitates a more detailed identification of diagnostic biomarkers that can reflect its diverse pathogenic pathways.
Humans Oxidative Phosphorylation Machine Learning Intercellular Signaling Peptides and Proteins Biomarkers Captopril Glycoproteins Molecular Docking Simulation Extracellular Matrix Proteins Heart Failure Carrier Proteins
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Machine learning compensates fold-change method and highlights oxidative phosphorylation in the brain transcriptome of Alzheimer's disease.

Scientific reports Jul 1, 2021
Alzheimer's disease (AD) is a neurodegenerative disorder causing 70% of dementia cases. However, the mechanism of disease development is still elusive. Despite the availability of a wide range of biological data, a comprehensive understanding of AD's...
Brain Alzheimer Disease Humans Transcriptome Oxidative Phosphorylation Machine Learning
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Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data.

PloS one Nov 8, 2019
Several studies have reported mitochondrial dysfunction in rheumatoid arthritis (RA). Many nuclear DNA (nDNA) encoded proteins translocate to mitochondria, but their participation in the dysfunction of this cell organelle during RA is quite unclear. ...
Inflammation Synovial Membrane Apoptosis Humans Models, Biological Gene Expression Profiling Gene Ontology Oxidative Phosphorylation Reactive Oxygen Species Mitochondria Protein Interaction Maps Mitochondrial Proteins Gene Expression Regulation Arthritis, Rheumatoid
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Analysis of differentially expressed genes in rheumatoid arthritis and osteoarthritis by integrated microarray analysis.

Journal of cellular biochemistry Mar 4, 2019
BACKGROUND: Rheumatoid arthritis (RA) and osteoarthritis (OA) were two major types of joint diseases. This study aimed to explore the mechanism underlying OA and RA and analyze their difference by integrated analysis of multiple gene expression data ...
Osteoarthritis Gene Expression Regulation Chemokines Oligonucleotide Array Sequence Analysis Oxidative Phosphorylation Humans Ubiquitin-Protein Ligases Arthritis, Rheumatoid Gene Ontology Gene Expression Profiling Signal Transduction Protein Interaction Maps Synovial Membrane Inhibitor of Apoptosis Proteins Gene Regulatory Networks
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Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning.

Scientific reports Jan 26, 2015
In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and mitochondrial morpho-functional changes. Empirical evidence suggests these aberratio...
Electron Transport Complex I Chromans Citrate (si)-Synthase Reactive Oxygen Species Humans Oxidative Phosphorylation Leigh Disease Membrane Potential, Mitochondrial Machine Learning Mitochondrial Diseases Mitochondria Fibroblasts
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Machine Learning Assisted Stroke Prediction in Mechanical Circulatory Support: Predictive Role of Systemic Mitochondrial Dysfunction.

ASAIO journal (American Society for Artificial Internal Organs : 1992) May 1, 2025
Stroke continues to be a major adverse event in advanced congestive heart failure (CHF) patients after continuous-flow left ventricular assist device (CF-LVAD) implantation. Abnormalities in mitochondrial oxidative phosphorylation (OxPhos) have been ...
Heart-Assist Devices Oxidative Phosphorylation Female Aged Male Mitochondria Heart Failure Middle Aged Stroke Humans Machine Learning
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Oxidative Phosphorylation Pathway in Ankylosing Spondylitis: Multi-Omics Analysis and Machine Learning.

International journal of rheumatic diseases May 1, 2025
INTRODUCTION: Ankylosing spondylitis (AS) is a chronic inflammatory disease affecting the axial skeleton, characterized by immune microenvironment dysregulation and elevated cytokines like TNF-α and IL-17. Mitochondrial oxidative phosphorylation (OXP...
Machine Learning Female Adult Male Humans Transcriptome Case-Control Studies Single-Cell Analysis RNA-Seq Middle Aged Leukocytes, Mononuclear Gene Expression Profiling Mitochondria Oxidative Phosphorylation Spondylitis, Ankylosing Gene Regulatory Networks Multiomics Signal Transduction
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