Visualizing fatigue mechanisms in non-communicable diseases: an integrative approach with multi-omics and machine learning.

Journal: BMC medical informatics and decision making
Published Date: Jun 3, 2025

Abstract

BACKGROUND: Fatigue is a prevalent and debilitating symptom of non-communicable diseases (NCDs); however, its biological basis are not well-defined. This exploratory study aimed to identify key biological drivers of fatigue by integrating metabolomic, microbiome, and genetic data from blood and saliva samples using a multi-omics approach.

Authors

  • Yusuke Kobayashi
    Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
  • Naoki Fujiwara
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  • Yuki Murakami
    Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
  • Shoichi Ishida
    Graduate School of Medical Life Science, Yokohama City University, Yokohama, Kanagawa 230-0045, Japan.
  • Sho Kinguchi
    Department of Nephrology and Hypertension, Yokohama City University Medical Center, Yokohama, Japan.
  • Tatsuya Haze
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Department of Nephrology and Hypertension, Yokohama City University Medical Center, Yokohama, Japan; YCU Center for Novel and Exploratory Clinical Trials (Y-NEXT), Yokohama City University Hospital, Yokohama, Japan. Electronic address: haze.tat.bg@yokohama-cu.ac.jp.
  • Kengo Azushima
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  • Akira Fujiwara
    Department of Nephrology and Hypertension, Yokohama City University Medical Center, Yokohama, Japan.
  • Hiromichi Wakui
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  • Masayoshi Sakakura
    Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
  • Kei Terayama
    Graduate School of Medical Life Science, Yokohama City University, Yokohama, Kanagawa 230-0045, Japan.
  • Nobuhito Hirawa
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Department of Nephrology and Hypertension, Yokohama City University Medical Center, Yokohama, Japan; Clinical Education and Training Center, Yokohama City University Medical Center, Yokohama, Japan.
  • Tetsuo Isozaki
    Koiso Medical Clinic, Yokosuka, Japan.
  • Hiroaki Yasuzaki
    Kotani Medical Clinic, Yokohama, Japan.
  • Hajime Takase
    YCU Center for Novel and Exploratory Clinical Trials (Y-NEXT), Yokohama City University Hospital, Yokohama, Japan; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  • Yuichiro Yano
    Department of General Medicine, Juntendo University Faculty of Medicine, 2-1-1, Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan, 81 3-3813-3111.
  • Kouichi Tamura
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

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