Preoperative blood and CT-image nutritional indicators in short-term outcomes and machine learning survival framework of intrahepatic cholangiocarcinoma.

Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Published Date: Jun 1, 2025

Abstract

BACKGROUND&AIMS: Intrahepatic cholangiocarcinoma (iCCA) is aggressive with limited treatment and poor prognosis. Preoperative nutritional status assessment is crucial for predicting outcomes in patients. This study aimed to compare the predictive capabilities of preoperative blood like albumin-bilirubin (ALBI), controlling nutritional status (CONUT), prognostic nutritional index (PNI) and CT-imaging nutritional indicators like skeletal muscle index (SMI), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), visceral to subcutaneous adipose tissue ratio (VSR) in iCCA patients undergoing curative hepatectomy.

Authors

  • Mingxun Wang
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
  • Xiaozai Xie
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China. Electronic address: xxiaozai@hotmail.com.
  • Jiacheng Lin
    Key Lab. of Advanced Manufacturing Technology of Ministry of Education, Guizhou University, Guiyang, China.
  • Zefeng Shen
    Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
  • Enguang Zou
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China. Electronic address: zoureoer@outlook.com.
  • Yi Wang
    Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Xiao Liang
    Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, Beijing Laboratory for Food Quality and Safety, Beijing, 100193, People's Republic of China; College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, People's Republic of China.
  • Gang Chen
    Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Haitao Yu
    Department of Fundamental Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China.

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