Transcriptome-wide analysis reveals potential roles of CFD and ANGPTL4 in fibroblasts regulating B cell lineage for extracellular matrix-driven clustering and novel avenues for immunotherapy in breast cancer.

Journal: Molecular medicine (Cambridge, Mass.)
PMID: 40340806

Abstract

BACKGROUND: The remodeling of the extracellular matrix (ECM) plays a pivotal role in tumor progression and drug resistance. However, the compositional patterns of ECM in breast cancer and their underlying biological functions remain elusive.

Authors

  • Hongwei Wang
    Department of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, 150000, Heilongjiang Province, China.
  • Yu-Nan Zhu
    Department of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, 150000, Heilongjiang Province, China.
  • Sifan Zhang
    Department of Neurobiology, Harbin Medical University, Harbin, 150081, Heilongjiang Province, China.
  • Kexin Liu
    Department of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, 150000, Heilongjiang Province, China.
  • Rong Huang
    School of Nursing, Chuanbei Medical College, Nanchong, China.
  • Zhigao Li
    Department of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, 150000, Heilongjiang Province, China. lzg_1964@yeah.net.
  • Lan Mei
    Department of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, 150000, Heilongjiang Province, China. meilanmm@sina.com.
  • Yingpu Li
    Department of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, 150000, Heilongjiang Province, China. liyingpu@hrbmu.edu.cn.

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