Vedolizumab in inflammatory bowel disease: Real-world outcomes and their prediction with machine learning-the IG-IBD LIVE study.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Published Date:

Abstract

BACKGROUND AND AIMS: Real-world studies on vedolizumab in inflammatory bowel disease (IBD) are often limited by small sample size and short follow-up. In this study, we investigated the 2-year effectiveness and safety of vedolizumab in patients with IBD, and applied eXplainable Artificial Intelligence (XAI) to identify predictors of both.

Authors

  • Daniela Pugliese
    Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, L. Go A. Gemelli 8, 00168 Rome, Italy; UOC Pronto Soccorso, Medicina d'Urgenza e Medicina Interna, Ospedale Isola Tiberina Gemelli Isola, 00186 Rome, Italy; UOS Gastroenterologia, Ospedale Isola Tiberina Gemelli Isola, 00186 Rome, Italy.
  • Giuseppe Privitera
    Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  • Nicola Cersullo
    Institute of mechanics and adaptronics, TU Braunschweig.
  • Harsh Bordekar
    Institute of mechanics and adaptronics, TU Braunschweig.
  • Federica Crispino
    IBD Unit, Villa Sofia-Cervello Hospital, Palermo, Italy.
  • Nicolò Mezzina
    Department of Biochemical and Clinical Science "L. Sacco" ASST Fatebenefratelli Sacco-University of Milan, Italy.
  • Lucienne Pellegrini
    Gastroenterology, Federico II University Hospital, Napoli, Campania, Italy.
  • Mariangela Allocca
    Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Milano, Lombardia, Italy.
  • Lucrezia Laterza
    CEMAD - IBD UNIT, Unità Operativa Complessa di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
  • Anna Viola
    UOSD Malattie Intestinali Croniche, Dip. Di Medicina Clinica e Sperimentale, Policlinico Messina, Sicily, Italy.
  • Lorenzo Bertani
    Gastroenterology and Digestive Endoscopy Department of Medical Specialties Apuane Hospital, Tuscany North-West ASL, Massa, Italy.
  • Pietro Soru
    Gastroenterology and Endoscopy Unit, La Fondazione IRCCS Ca' Granda Ospedale Maggiore di Milano Policlinico, Department of Pathophysiology and Transplantation, University of Milan, Milano, Lombardia, Italy.
  • Barbara Scrivo
    Head IBD Clinic, Gastroenterology Section, Promise, University of Palermo, Sicily, Italy.
  • Brigida Barberio
    Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
  • Chiara Ricci
    Gastroenterology Unit, Clinical and Experimental Sciences Department, Spedali Civili Hospital, University of Brescia, Brescia, Italy.
  • Paola Balestrieri
    Unit of Digestive Disease of Campus Bio Medico University of Rome, Italy.
  • Marco Daperno
    Gastroenterology Unit, Azienda Ospedaliera Ordine Mauriziano di Torino, Torino, Piemonte, Italy.
  • Dario Pluchino
    Gastroenterology Unit, A.O.U. Policlinico "Vittorio Emanuele" Catania Italy.
  • Fernando Rizzello
    Policlinico Sant'Orsola Malpighi, Department of Internal Medicine and Gastroenterology, Bologna, Italy.
  • Maria Lia Scribano
    Villa Stuart Multi-Speciality Clinic, Rome, Italy.
  • Renato Sablich
    Gastroenterology Unit, Santa Maria degli Angeli Hospital, Pordenone, Italy.
  • Luca Pastorelli
    Gastroenterology and Hepatology Unit, ASST Santi Paolo e Carlo, 20142 Milan, Italy.
  • Francesco Manguso
    AO Cardarelli, Surgical Department, Naples, Italy.
  • Angela Variola
    IBD Unit, IRCCS Sacro Cuore Don Calabria, Negrar di Valpolicella, Verona, Italy.
  • Antonio Di Sario
    Clinica di Gastroenterologia, Università Politecnica delle Marche, IBD-UNIT and Dipartimento Gastroenterologico e dei Trapianti, Polo Ospedaliero-Universitario "Umberto I-G.M. Lancisi- G. Salesi", Ancona, Italy.
  • Laurino Grossi
    G D'Annunzio University-Digestive Physiopathology Ospedale Spirito Santo Pescara, Pescara, Italy.
  • Davide Giuseppe Ribaldone
    Department of Medical Sciences, University of Turin, Turin, Italy.
  • Giuseppe Biscaglia
    Division of Gastroenterology and Endoscopy, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
  • Andrea Buda
    Department of Gastrointestinal Oncological Surgery, Gastroenterology and Endoscopy Unit, S. Maria del Prato Hospital, Feltre, Italy.
  • Giammarco Mocci
    SC Gastroenterologia Ospedale Brotzu, Cagliari, Italy.
  • Angelo Viscido
    Gastroenterology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Maria Carla Di Paolo
    Department of Gastroenterology and Digestive Endoscopy, S. Giovanni Addolorata Hospital, Rome, Italy.
  • Sara Onali
    Gastroenterology Unit, University Hospital AOU Cagliari, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
  • Stefano Rodino'
    Division of Gastroenterology, 'Ciaccio-Pugliese' Hospital, Catanzaro, Italy.
  • Marina Coletta
    Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
  • Mariabeatrice Principi
    University of Bari, Gastroenterology, Bari, Italy.
  • Agnese Miranda
    Gastroenterology and Endoscopy Unit, University of Campania "L. Vanvitelli" Naples, Italy.
  • Arnaldo Amato
    Ospedale Valduce, Gastroenterology, Como, Italy.
  • Cristina Bezzio
    Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
  • Carlo Petruzzellis
    Department of Medicine, Gastroenterology and Endoscopy, Fondazione Poliambulanza, Brescia, Italy.
  • Silvia Mazzuoli
    Section of Gastroenterology & Artificial Nutrition, Hospital San Nicola Pellegrino, Bari, Italy.
  • Stefano Festa
    S. Filippo Neri Hospital, IBD Unit, Rome, Lazio, Italy.
  • Alessandro Sartini
    Gastroenterology and Digestive Endoscopy Unit, Forlì-Cesena, AUSL della Romagna, Italy.
  • Davide Checchin
    UO.C. Gastroenterologia, Ospedale HUB di Mestre, Venezia, Italy.
  • Libera Fanigliulo
    Gastroenterology Unit, Ospedale Santissima Annunziata, Taranto, Italy.
  • Sara Gallina
    Division of Gastroenterology, 'Belcolle' Hospital, Viterbo, Italy.
  • Monica Cesarini
    Casa di Cura "Madonna della fiducia", Roma, Italy.
  • Giorgia Bodini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy. Electronic address: giorgia.bodini@edu.unige.it.
  • Davide Stradella
    Gastroenterologia, A.O.U Maggiore della Caritá di Novara, Piemonte, University of Eastern Piedmont Amedeo Avogadro, Italy.
  • Rocco Spagnuolo
    Gastroenterology and Digestive Endoscopy Department, University of Catanzaro, Catanzaro, Italy.
  • Luisa Guidi
    CEMAD - IBD UNIT, Unità Operativa Complessa di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
  • Edoardo Savarino
    Gastroenterolgy Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
  • Maria Cappello
    Head IBD Clinic, Gastroenterology Section, Promise, University of Palermo, Sicily, Italy.
  • Flavio Caprioli
    Gastroenterology and Endoscopy Unit, La Fondazione IRCCS Ca' Granda Ospedale Maggiore di Milano Policlinico, Department of Pathophysiology and Transplantation, University of Milan, Milano, Lombardia, Italy.
  • Francesco Costa
    Department of Neurosurgery, Humanitas Research Hospital, Rozzano, Italy.
  • Walter Fries
    UOSD Malattie Intestinali Croniche, Dip. Di Medicina Clinica e Sperimentale, Policlinico Messina, Sicily, Italy.
  • Franco Scaldaferri
    CEMAD - IBD UNIT, Unità Operativa Complessa di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
  • Gionata Fiorino
    Gastroenterology and Digestive Endoscopy, San Camillo-Forlanini Hospital, Rome, Italy.
  • Fabiana Castiglione
    Gastroenterology, Federico II University Hospital, Napoli, Campania, Italy.
  • Alessandro Massari
    Department of Biochemical and Clinical Science "L. Sacco" ASST Fatebenefratelli Sacco-University of Milan, Italy.
  • Ambrogio Orlando
    IBD Unit, Villa Sofia-Cervello Hospital, Palermo, Italy.
  • Alessandro Armuzzi
    Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. Electronic address: alessandro.armuzzi@hunimed.eu.