Detection of Early-Stage Colorectal Cancer Using Cell-Free oncRNA Biomarkers and Artificial Intelligence.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Published Date: Aug 1, 2025

Abstract

PURPOSE: Colorectal cancer is the second leading cause of cancer-related deaths worldwide, and early detection significantly improves treatment outcomes, but existing blood-based tests often have limited sensitivity in early-stage disease. We developed a blood-based test combining orphan noncoding RNAs (oncRNA), a group of small cell-free RNAs, with generative artificial intelligence to detect colorectal cancer.

Authors

  • Amir Momen-Roknabadi
    Exai Bio, Palo Alto, United States.
  • Mehran Karimzadeh
    Exai Bio Inc., Palo Alto, California, United States.
  • Nae-Chyun Chen
    Department of Computer Science, Johns Hopkins University, Baltimore, MD, 21218, USA. cnaechy1@jhu.edu.
  • Taylor B Cavazos
    University of California, San Francisco, San Francisco, California, United States.
  • Jieyang Wang
    Exai Bio, Palo Alto, United States.
  • Jeremy Ku
    Exai Bio, Palo Alto, United States.
  • Alex Degtiar
    Exai Bio, Palo Alto, United States.
  • Akshaya Krishnan
    Exai Bio, Palo Alto, United States.
  • Martha Hernandez
    Exai Bio, Palo Alto, United States.
  • Magdalena Gebala
    Exai Bio, Palo Alto, United States.
  • Alice Huang
    Columbia University Irving Medical Center, 622 W 168th St, New York, NY 10032, United States of America. Electronic address: alh9176@nyp.org.
  • Selina Chen
    Exai Bio, Palo Alto, United States.
  • Dang Nguyen
    Massachusetts General Hospital, Corrigan Minehan Heart Center, Harvard Medical School, Boston, MA, USA.
  • Ti Lam
    Exai Bio, Palo Alto, United States.
  • Rose Hanna
    Exai Bio, Palo Alto, United States.
  • Lisa Fish
    University of California, San Francisco, San Francisco, CA, United States.
  • Alexx J Smith
    Exai Bio, Palo Alto, United States.
  • Sukh Sekhon
    Exai Bio, Palo Alto, United States.
  • Jennifer Yen
    Guardant Health, Redwood City, CA, United States.
  • Jeff Gregg
    University of Nevada Reno, United States.
  • Helen Li
    Exai Bio, Palo Alto, United States.
  • Fereydoun Hormozdiari
    University of California, Davis, Sacramento, United States.
  • Babak Behsaz
    Google Health, Cambridge, MA 02142, USA.
  • Anna Hartwig
    Exai Bio, Palo Alto, United States.
  • Hani Goodarzi
    Department of Biochemistry and Biophysics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States.
  • Lee Schwartzberg
    University of Nevada Reno, United States.
  • Babak Alipanahi
    Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada. Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada. Program on Genetic Networks and Program on Neural Computation & Adaptive Perception, Canadian Institute for Advanced Research, Toronto, Ontario M5G 1Z8, Canada.

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