CLIC1 and IFITM2 expression in brain tissue correlates with cognitive impairment via immune dysregulation in sepsis and Alzheimer's disease.

Journal: International immunopharmacology
Published Date: Apr 10, 2025

Abstract

BACKGROUND: Sepsis, a life-threatening condition driven by dysregulated host responses to infection, is associated with long-term cognitive impairments resembling Alzheimer's disease (AD). However, the molecular mechanisms linking sepsis-induced cognitive dysfunction and AD remain unclear. We hypothesized that shared genetic pathways underlie cognitive deficits in both conditions.

Authors

  • Xiaoyu Xiang
    Department of Critical Care Medicine, West China Hospital, Sichuan University and Institute of Critical Care Medicine, Chengdu, Sichuan Province, China.
  • Zhongxue Feng
    Department of Critical Care Medicine, West China Hospital, Sichuan University and Institute of Critical Care Medicine, Chengdu, Sichuan Province, China.
  • Lijun Wang
    Department of Stomatology, The Third Medical Center Chinese PLA General Hospital Beijing China.
  • Denian Wang
    Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.
  • Tingting Li
    Key Laboratory of Biotechnology and Bioresources Utilization (Dalian Minzu University), Ministry of Education, Dalian, China.
  • Jing Yang
    Beijing Novartis Pharma Co. Ltd., Beijing, China.
  • Siying Wang
    Department of Ophthalmology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Lu Ding Road # 355, Shanghai, 200000, China.
  • Fei Xiao
    Peking University Fifth School of Clinical Medicine, Beijing, China.
  • Wei Zhang
    The First Affiliated Hospital of Nanchang University, Nanchang, China.

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