Transforming the management of radiotherapy-induced hypothyroidism in nasopharyngeal carcinoma through an Innovative individualized radiation dosage model: A multicenter retrospective analysis.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Published Date: Jul 1, 2025

Abstract

PURPOSE: Current guidelines for thyroid radiation dose prescription lack uniformity and fail to consider the unique characteristics of individual patients. This study aimed to develop an individualized thyroid dosing regimen to enhance thyroid protection during radiotherapy.

Authors

  • Jianming Ding
    Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
  • Xiaoyan Yin
    Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China.
  • Yuhao Lin
    Department of Endocrinology, Xiamen Humanity Hospital Fujian Medical University, Xiamen, Fujian, China.
  • Xiyi Liao
    Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
  • Lisha Chen
    Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
  • Jiabiao Hong
    Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
  • Linghui Yan
    Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
  • Sijia Chen
    Danone Open Science Research Center, Shanghai, China.
  • Xueting Yan
    Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  • Zirong Li
    Department of Orthopedics, Beijing Key Laboratory for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Peking Union Medical College, Beijing 100029, China.
  • Kai Hu
    State Key Laboratory of Information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University, Wuhan, China.
  • Ruiping Zhai
    Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. Electronic address: mmaozhai@163.com.
  • Chuanben Chen
    Department of Radiation Oncology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, China. chenchuanben2010@126.com.
  • Zhaodong Fei
    Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China. Electronic address: feizhaodong@fjmu.edu.cn.

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