Menopausal hormone therapy and the female brain: Leveraging neuroimaging and prescription registry data from the UK Biobank cohort.

Journal: eLife
Published Date: May 29, 2025

Abstract

BACKGROUND: Menopausal hormone therapy (MHT) is generally thought to be neuroprotective, yet results have been inconsistent. Here, we present a comprehensive study of MHT use and brain characteristics in females from the UK Biobank.

Authors

  • Claudia Barth
    Division for Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
  • Liisa A M Galea
    Department of Psychology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
  • Emily G Jacobs
    Psychological and Brain Sciences, University of California Santa Barbara, Santa Barbara, United States.
  • Bonnie H Lee
    Centre for Addiction and Mental Health, Toronto, Canada.
  • Lars T Westlye
    CoE NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Ann-Marie G de Lange
    LREN, Centre for Research in Neurosciences, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne.

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