NeoPred: dual-phase CT AI forecasts pathologic response to neoadjuvant chemo-immunotherapy in NSCLC.

Journal: Journal for immunotherapy of cancer
Published Date:

Abstract

BACKGROUND: Accurate preoperative prediction of major pathological response or pathological complete response after neoadjuvant chemo-immunotherapy remains a critical unmet need in resectable non-small-cell lung cancer (NSCLC). Conventional size-based imaging criteria offer limited reliability, while biopsy confirmation is available only post-surgery.

Authors

  • Jianqi Zheng
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
  • Zeping Yan
    Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou, China; National Clinical Research Center for Respiratory Disease, Guangzhou, China; Guangzhou Institute of Respiratory Health, Guangzhou, China.
  • Runchen Wang
    National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
  • Houlu Xiao
    Yuefa Health Technology (Guangzhou) Co., Ltd, Guangzhou, Guangdong, China.
  • Zhenlin Chen
    Department of Biomedical Engineering, City University of Hong Kong, Kowloong Tong, Hong Kong, China.
  • Xiaomin Ge
    Yuefa Health Technology (Guangzhou) Co., Ltd, Guangzhou, Guangdong, China.
  • Zhigang Li
    Hefei Institute of Physical Science, Chinese Academy of Sciences Hefei 230036 PR China liuyong@aiofm.ac.cn zhanglong@aiofm.ac.cn wangchongwen1987@126.com.
  • Zhichao Liu
    a Division of Bioinformatics and Biostatistics , National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson , AR , USA.
  • Hong Yu
    University of Massachusetts Medical School, Worcester, MA.
  • Hongxu Liu
  • Guan Wang
    School of Information Science and Technology, Beijing Forestry University, Beijing 100083, China.
  • Pingwen Yu
    Department of Thoracic Surgery, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China.
  • Junke Fu
    Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Guangjian Zhang
    Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Jia Zhang
    Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • Bohao Liu
    Sun Yat-sen Memorial Hospital and Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Ying Huang
    Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Southwest Medical University Luzhou, Sichuan, China.
  • Hongshen Deng
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
  • Chudong Wang
    Guangzhou Medical University, Guangzhou 511436, China. Electronic address: stwcdde@163.com.
  • Wenhai Fu
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
  • Yuan Zhang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Rui Wang
    Department of Clinical Laboratory Medicine Center, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia, China.
  • Yu Jiang
    School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, China.
  • Yuechun Lin
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
  • Linchong Huang
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
  • Chao Yang
    Translational Institute for Cancer Pain, Chongming Hospital Affiliated to Shanghai University of Health & Medicine Sciences (Xinhua Hospital Chongming Branch), Shanghai 202155, P. R. China.
  • Fei Cui
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
  • Jianxing He
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
  • Hengrui Liang
    China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.