Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi-Ethnic Study of Atherosclerosis.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
Published Date:

Abstract

INTRODUCTION: We aimed to examine the global impact of brain small vessel disease (SVD) on cognitive performance.

Authors

  • Sokratis Charisis
    Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Tanweer Rashid
    Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Christina Dintica
    Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, California, USA.
  • Mitzi Gonzales
    Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Hangfan Liu
    Neuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC), Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
  • Jeffrey B Ware
    Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Thomas R Austin
    Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Paul N Jensen
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.
  • Alison E Fohner
    Division of Research, Kaiser Permanente, Oakland, California, USA.
  • Jordan E Tanley
    Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
  • Jingzhong Ding
    Section of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • José A Luchsinger
    Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, New York, USA.
  • Bonnie Sachs
    Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Ilya M Nasrallah
    Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for and Data Science for Integrated Diagnostics (AID), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • R Nick Bryan
    Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 (J.D.R., L.X., A.K., J.M.E., T.C., I.M.N., S.M., J.C.G.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, Calif (J.D.R., A.M.R.); Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, Pa (X.L., J.W.); University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (M.T.D.); Mecklenburg Radiology Associates, Charlotte, NC (E.J.B.); Department of Radiology, University of Texas, Austin, Tex (R.N.B.); and Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, Pa (I.M.N.).
  • Kathleen M Hayden
    Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • David Wolk
    Alzheimer's Disease Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Katya Rascovsky
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Christos Davatzikos
    Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for and Data Science for Integrated Diagnostics (AID), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • William T Longstreth
    Department of Epidemiology, University of Washington, Seattle, Washington, USA.
  • Kristine Yaffe
    Departments of Neurology, Psychiatry and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
  • Sudha Seshadri
    The Framingham Heart Study, Framingham, MA 01701, USA.
  • Susan R Heckbert
    Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Timothy Hughes
    Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
  • Mohamad Habes
    Biggs Alzheimer's Institute, University of Texas San Antonio Health Science Center, USA.