The major vascular cause of dementia is cerebral small vessel disease (SVD). Its diagnosis relies on imaging hallmarks, such as white matter hyperintensities (WMH). WMH present a heterogenous pathology, including myelin and axonal loss. Yet, these mi...
BACKGROUND: Cerebral small vessel disease (CSVD) is a major cause of stroke, particularly in the elderly population, leading to significant morbidity and mortality. Accurate identification of high-risk patients and timing of stroke occurrence plays a...
BACKGROUND: Cerebral small vessel disease is the most common pathology underlying vascular dementia. In small vessel disease, diffusion tensor imaging is more sensitive to white matter damage and better predicts dementia risk than conventional magnet...
Cerebral microbleeds (CMB) represent a feature of cerebral small vessel disease (cSVD), a prominent vascular contributor to age-related cognitive decline, dementia, and stroke. They are visible as spherical hypointense signals on T2*- or susceptibili...
White matter hyperintensities (WMH) of presumed vascular origin are a magnetic resonance imaging (MRI)-based biomarker of cerebral small vessel disease (CSVD). WMH are associated with cognitive decline and increased risk of stroke and dementia, and a...
Alzheimer's & dementia : the journal of the Alzheimer's Association
39410879
INTRODUCTION: Oculomotor and gait dysfunctions are closely associated with cognition. However, oculo-gait patterns and their correlation with cognition in cerebral small vessel disease (CSVD) remain unclear.
Disorders of the central nervous system, including neurodegenerative diseases, frequently affect the brainstem and can present with focal atrophy. This study aimed to (1) optimize deep learning-based brainstem segmentation for a wide range of patholo...
Cognitive impairment in cerebral small vessel disease (CSVD) progresses subtly but carries significant clinical consequences, necessitating effective diagnostic tools. This study developed and validated predictive models for CSVD-related cognitive im...
The heterogeneity of cerebral small vessel disease (CSVD) with mild cognitive impairment (MCI) presents a challenge for diagnosis and classification. This study aims to propose a multimodal magnetic resonance imaging (MRI)-based machine learning fram...
PURPOSE: The aim of this study was to assess retinal microvascular parameters (RMPs) in Fabry disease (FD) using deep learning, and analyze the correlation with brain lesions related to cerebral small vessel disease (CSVD).