Structural and metabolic topological alterations associated with butylphthalide treatment in mild cognitive impairment: Data from a randomized, double-blind, placebo-controlled trial.

Journal: Psychiatry and clinical neurosciences
Published Date: Mar 31, 2025

Abstract

AIMS: Effective intervention for mild cognitive impairment (MCI) is key for preventing dementia. As a neuroprotective agent, butylphthalide has the potential to treat MCI due to Alzheimer disease (AD). However, the pharmacological mechanism of butylphthalide from the brain network perspective is not clear. Therefore, we aimed to investigate the multimodal brain network changes associated with butylphthalide treatment in MCI due to AD.

Authors

  • Xiaodong Han
    Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Shuting Gong
    School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
  • Jin Gong
    College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
  • Pin Wang
    College of Communication Engineering, Chongqing University, Chongqing, 400044, China.
  • Ruina Li
    School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
  • Runqi Chen
    School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
  • Chang Xu
    Institute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian 116089, China.
  • Wenxian Sun
    Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Shaoqi Li
    College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
  • Yufei Chen
    College of Electronics and Information Engineering, Tongji University, Shanghai 200092, China. Electronic address: yufeichen@tongji.edu.cn.
  • Yuting Yang
  • Heya Luan
    Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Boye Wen
    Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Jinxuan Guo
    College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
  • Sirong Lv
    Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Cuibai Wei
    Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.

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