Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration.

Journal: Journal of neurology
Published Date:

Abstract

INTRODUCTION: Recent research has suggested that neuroinflammation may be important in the pathogenesis of neurodegenerative diseases. Free-water diffusion (FWD) has been proposed as a non-invasive neuroimaging-based biomarker for neuroinflammation.

Authors

  • Vishaal Sumra
    Institute of Medical Science, University of Toronto, Medical Sciences Building, 1 King's College Cir Suite 2374, Toronto, ON, M5S 1A8, Canada. Vishaal.sumra@mail.utoronto.ca.
  • Mohsen Hadian
    Krembil Brain Institute, 135 Nassau St, Toronto, ON, M5T 1M8, Canada.
  • Allison A Dilliott
    Montreal Neurological Institute and Hospital, 3801 Rue University, Montréal, QC, H3A 2B4, Canada.
  • Sali M K Farhan
    Montreal Neurological Institute and Hospital, 3801 Rue University, Montréal, QC, H3A 2B4, Canada.
  • Andrew R Frank
    University of Ottawa, 75 Laurier Ave E, Ottawa, ON, K1N 6N5, Canada.
  • Anthony E Lang
    The Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Canada.
  • Angela C Roberts
    School of Communication Sciences and Disorders, University of Western Ontario, London, Canada.
  • Angela Troyer
    Baycrest Health Sciences Centre, 3560 Bathurst St, Toronto, ON, M6A 2E1, Canada.
  • Stephen R Arnott
    Rotman Research Institute, Baycrest, Toronto, ON, Canada.
  • Connie Marras
    ICES, Life Stage Research Program, Toronto, Ontario, Canada.
  • David F Tang-Wai
    University Health Network, 190 Elizabeth St, Toronto, ON, M5G 2C4, Canada.
  • Elizabeth Finger
    From the Department of Neuroimaging (A.L.Y., S.C.R.W.), Institute of Psychiatry, Psychology and Neuroscience, King's College London; Departments of Computer Science (A.L.Y., D.C.A.) and Medical Physics and Biomedical Engineering (D.M.C.), Centre for Medical Image Computing, University College London; Dementia Research Centre (M.B., L.L.R., R.S.C., G.P., E.T., D.M.C., C.V.G., L.J., J.D.R.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK; Department of Neurology (J.v.S., L.J., H.S.), Erasmus Medical Centre, Rotterdam, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital; Neuroscience Area (F.M.), Biodonostia Health Research Institute, San Sebastian, Gipuzkoa, Spain; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Neurology Unit (B.B.), Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Faculté de Médecine (R.L.), Université Laval, Québec; Sunnybrook Health Sciences Centre, Sunnybrook Research Institute (M.M.), and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Canada; Center for Alzheimer Research (C.G.), Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Bioclinicum, Karolinska Institutet; Unit for Hereditary Dementias (C.G.), Theme Aging, Karolinska University Hospital, Solna, Sweden; Fondazione Ca'Granda (D.G.), IRCCS Ospedale Policlinico; University of Milan (D.G.), Centro Dino Ferrari, Italy; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology, Department of Neurosciences (R.V.), and Leuven Brain Institute (R.V.), KU Leuven; Neurology Service (R.V.), University Hospitals Leuven, Belgium; Faculty of Medicine (A.d.M.), University of Lisbon, Portugal; Fondazione IRCCS Istituto Neurologico Carlo Besta (F.T.), Milan, Italy; University Hospital of Coimbra (HUC), Neurology Service (I.S.), and Center for Neuroscience and Cell Biology (I.S.), Faculty of Medicine, University of Coimbra, Portugal; Department of Psychiatry, McGill University Health Centre (S.D.), and McConnell Brain Imaging Centre, Montreal Neurological Institute (S.D.), McGill University, Montreal, Canada; Nuffield Department of Clinical Neurosciences (C.B.), Medical Sciences Division, University of Oxford; Division of Neuroscience and Experimental Psychology (A.G.), Wolfson Molecular Imaging Centre, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), University of Duisburg-Essen; Department of Neurology (J.L., A.D.), Ludwig-Maximilians Universität München; German Center for Neurodegenerative Diseases (DZNE) (J.L.); Munich Cluster of Systems Neurology (SyNergy) (J.L.), Munich; Department of Neurology (M.O.), University of Ulm, Germany; Departments of Neuroscience, Psychology, Drug Research, and Child Health (S.S.), University of Florence; and IRCCS Don Gnocchi (S.S.), Florence, Italy.
  • Ekaterina Rogaeva
    Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Medical Sciences Building, 1 King's College Cir Suite 2374, Toronto, ON, M5S 1A8, Canada.
  • Joseph B Orange
    School of Communication Sciences and Disorders, University of Western Ontario, 1151 Richmond St, London, ON, N6A 3K7, Canada.
  • Joel Ramirez
    LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
  • Lorne Zinman
  • Malcolm Binns
    Rotman Research Institute, 3560 Bathurst St, Toronto, ON, M6A 2E1, Canada.
  • Michael Borrie
    Division of Geriatric Medicine, University of Western Ontario, London, ON, Canada.
  • Morris Freedman
    Baycrest Health Sciences Centre, 3560 Bathurst St, Toronto, ON, M6A 2E1, Canada.
  • Miracle Ozzoude
    LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
  • Robert Bartha
    Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Robarts Research Institute, University of Western Ontario, London, Canada.
  • Richard H Swartz
    Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada.
  • David Munoz
    Unity Health Toronto, 61 Queen St E, Toronto, ON, M5C 2T2, Canada.
  • Mario Masellis
    Canadian Partnership for Stroke Recovery, Heart and Stroke Foundation, Toronto, Ontario, Canada.
  • Sandra E Black
    Institute of Medical Science, University of Toronto, Toronto, ON Canada.
  • Roger A Dixon
    Department of Psychology Science, University of Alberta, 116 St & 85 Ave, Edmonton, AB, T6G 2R3, Canada.
  • Dar Dowlatshahi
    Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.
  • David Grimes
    Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Ayman Hassan
    Northern Ontario School of Medicine, 935 Ramsey Lake Rd, Sudbury, ON, P3E 2C6, Canada.
  • Robert A Hegele
    Schulich School of Medicine& Dentistry, Division of Geriatric Medicine, Western University, 1151 Richmond St, London, ON, N6A 3K7, Canada.
  • Sanjeev Kumar
    Department of Informatics, Technical University of Munich, Germany.
  • Stephen Pasternak
    Robarts Research Institute, Western University, 1151 Richmond St, London, ON, N6A 3K7, Canada.
  • Bruce Pollock
    School of Communication Sciences and Disorders, University of Western Ontario, 1151 Richmond St, London, ON, N6A 3K7, Canada.
  • Tarek Rajji
    Centre for Addiction and Mental Health, 1000 Queen St W, Toronto, ON, M6J 1H4, Canada.
  • Demetrios Sahlas
    McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Gustavo Saposnik
    Stroke Outcomes and Decision Neuroscience Research Unit, Division of Neurology, Department of Medicine and Li Ka Shing Knowledge Institute, St.Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Maria Carmela Tartaglia
    From the Department of Neuroimaging (A.L.Y., S.C.R.W.), Institute of Psychiatry, Psychology and Neuroscience, King's College London; Departments of Computer Science (A.L.Y., D.C.A.) and Medical Physics and Biomedical Engineering (D.M.C.), Centre for Medical Image Computing, University College London; Dementia Research Centre (M.B., L.L.R., R.S.C., G.P., E.T., D.M.C., C.V.G., L.J., J.D.R.), Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK; Department of Neurology (J.v.S., L.J., H.S.), Erasmus Medical Centre, Rotterdam, the Netherlands; Cognitive Disorders Unit (F.M.), Department of Neurology, Donostia University Hospital; Neuroscience Area (F.M.), Biodonostia Health Research Institute, San Sebastian, Gipuzkoa, Spain; Alzheimer's Disease and Other Cognitive Disorders Unit (R.S.-V.), Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain; Neurology Unit (B.B.), Department of Clinical and Experimental Sciences, University of Brescia, Italy; Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Faculté de Médecine (R.L.), Université Laval, Québec; Sunnybrook Health Sciences Centre, Sunnybrook Research Institute (M.M.), and Tanz Centre for Research in Neurodegenerative Diseases (M.C.T.), University of Toronto, Canada; Center for Alzheimer Research (C.G.), Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Bioclinicum, Karolinska Institutet; Unit for Hereditary Dementias (C.G.), Theme Aging, Karolinska University Hospital, Solna, Sweden; Fondazione Ca'Granda (D.G.), IRCCS Ospedale Policlinico; University of Milan (D.G.), Centro Dino Ferrari, Italy; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust (J.B.R.), University of Cambridge, UK; Department of Clinical Neurological Sciences (E.F.), University of Western Ontario, London, Canada; Department of Neurodegenerative Diseases (M.S.), Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen; Center for Neurodegenerative Diseases (DZNE) (M.S.), Tübingen, Germany; Laboratory for Cognitive Neurology, Department of Neurosciences (R.V.), and Leuven Brain Institute (R.V.), KU Leuven; Neurology Service (R.V.), University Hospitals Leuven, Belgium; Faculty of Medicine (A.d.M.), University of Lisbon, Portugal; Fondazione IRCCS Istituto Neurologico Carlo Besta (F.T.), Milan, Italy; University Hospital of Coimbra (HUC), Neurology Service (I.S.), and Center for Neuroscience and Cell Biology (I.S.), Faculty of Medicine, University of Coimbra, Portugal; Department of Psychiatry, McGill University Health Centre (S.D.), and McConnell Brain Imaging Centre, Montreal Neurological Institute (S.D.), McGill University, Montreal, Canada; Nuffield Department of Clinical Neurosciences (C.B.), Medical Sciences Division, University of Oxford; Division of Neuroscience and Experimental Psychology (A.G.), Wolfson Molecular Imaging Centre, University of Manchester, UK; Departments of Geriatric Medicine and Nuclear Medicine (A.G.), University of Duisburg-Essen; Department of Neurology (J.L., A.D.), Ludwig-Maximilians Universität München; German Center for Neurodegenerative Diseases (DZNE) (J.L.); Munich Cluster of Systems Neurology (SyNergy) (J.L.), Munich; Department of Neurology (M.O.), University of Ulm, Germany; Departments of Neuroscience, Psychology, Drug Research, and Child Health (S.S.), University of Florence; and IRCCS Don Gnocchi (S.S.), Florence, Italy.