AIMC Topic: Neuroinflammatory Diseases
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Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration.
Journal of neurology
Jun 25, 2025
INTRODUCTION: Recent research has suggested that neuroinflammation may be important in the pathogenesis of neurodegenerative diseases. Free-water diffusion (FWD) has been proposed as a non-invasive neuroimaging-based biomarker for neuroinflammation.
Unveiling CNS cell morphology with deep learning: A gateway to anti-inflammatory compound screening.
PloS one
Mar 21, 2025
Deciphering the complex relationships between cellular morphology and phenotypic manifestations is crucial for understanding cell behavior, particularly in the context of neuropathological states. Despite its importance, the application of advanced i...
Identifying Neuro-Inflammatory Biomarkers of Generalized Anxiety Disorder from Lymphocyte Subsets Based on Machine Learning Approaches.
Neuropsychobiology
Jan 22, 2025
INTRODUCTION: Activation of the inflammatory response system is involved in the pathogenesis of generalized anxiety disorder (GAD). The purpose of this study was to identify and characterize inflammatory biomarkers in the diagnosis of GAD based on ma...
Cross-disease transcriptomic analysis reveals DOK3 and PAPOLA as therapeutic targets for neuroinflammatory and tumorigenic processes.
Frontiers in immunology
Dec 12, 2024
OBJECTIVE: Subarachnoid hemorrhage (SAH) and tumorigenesis share numerous biological complexities; nevertheless, the specific gene expression profiles and underlying mechanisms remain poorly understood. This study aims to identify differentially expr...
Dynamic changes in pyroptosis following spinal cord injury and the identification of crucial molecular signatures through machine learning and single-cell sequencing.
Journal of pharmaceutical and biomedical analysis
Aug 26, 2024
The pathological cascade of spinal cord injury (SCI) is highly intricate. The onset of neuroinflammation can exacerbate the extent of damage. Pyroptosis is a form of inflammation-linked programmed cell death (PCD), the inhibition of pyroptosis can pa...
Clinical applications of deep learning in neuroinflammatory diseases: A scoping review.
Revue neurologique
May 20, 2024
BACKGROUND: Deep learning (DL) is an artificial intelligence technology that has aroused much excitement for predictive medicine due to its ability to process raw data modalities such as images, text, and time series of signals.
Neonatal brain inflammation enhances methamphetamine-induced reinstated behavioral sensitization in adult rats analyzed with explainable machine learning.
Neurochemistry international
Apr 17, 2024
Neonatal brain inflammation produced by intraperitoneal (i.p.) injection of lipopolysaccharide (LPS) results in long-lasting brain dopaminergic injury and motor disturbances in adult rats. The goal of the present work is to investigate the effect of ...
Quercetin Exerts Anticonvulsant Effect through Mitigation of Neuroinflammatory Response in Pentylenetetrazole-induced Seizure in Mice.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria
Dec 31, 2023
Epilepsy is a chronic disease of the brain characterized by seizures. The currently available anticonvulsants only treat symptoms with serious adverse drug reactions. Therefore, there is need for new therapeutic intervention that will prevent epilept...
E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation in experimental stroke mice.
Journal of ethnopharmacology
Oct 30, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China...
Microglia
NF-kappa B
Anti-Inflammatory Agents
NLR Family, Pyrin Domain-Containing 3 Protein
Pyroptosis
Stroke
Infarction, Middle Cerebral Artery
Rats, Sprague-Dawley
Lipopolysaccharides
Plant Leaves
Neuroinflammatory Diseases
Mice
Rats
Inflammation
Anti-Infective Agents
Tumor Necrosis Factor-alpha
Interleukin-6
DNA-Binding Proteins
Animals
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