Plasma Cytokine and Chemokine Profiles Predict Efficacy and Toxicity of Anti-CD19 CAR-T Cell Therapy in Large B-Cell Lymphoma.

Journal: Clinical lymphoma, myeloma & leukemia
Published Date: Feb 20, 2025

Abstract

BACKGROUND: Anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a promising treatment for large B-cell lymphoma (LBCL); however, durable complete responses are achieved in only 30% to 40% of patients. Additionally, CAR-T therapy is frequently associated with significant toxicities, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS).

Authors

  • Fanyuan Zeng
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA; Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Hanwen Zhang
    Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, Shenzhen, China.
  • Shuhua Wang
    Landscape Architecture, Zhejiang Gongshang University, Hangzhou 310000, China.
  • Tenzin Passang
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA.
  • Yiwen Li
    College of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, China. xuyt@scu.edu.cn.
  • Christopher R Funk
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA.
  • Sarah Wyman
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA.
  • Colin B O'Leary
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA.
  • Aseala I Abousaud
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA.
  • Yuan Liu
    Department of General Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.
  • Manali Rupji
    Biostatistics Shared Resource, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
  • Kavita M Dhodapkar
    Department of Hematology and Medical Oncology, Children's Healthcare of Atlanta / Emory University, Atlanta, GA.
  • Edmund K Waller
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
  • Jean L Koff
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA. Electronic address: jkoff@emory.edu.

Keywords

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