Identifying threshold of CT-defined muscle loss after radiotherapy for survival in oral cavity cancer using machine learning.

Journal: European radiology
Published Date:

Abstract

OBJECTIVES: Muscle loss after radiotherapy is associated with poorer survival in patients with oral cavity squamous cell carcinoma (OCSCC). However, the threshold of muscle loss remains unclear. This study aimed to utilize explainable artificial intelligence to identify the threshold of muscle loss associated with survival in OCSCC.

Authors

  • Jie Lee
    Department of Medicine, MacKay Medical College, New Taipei City, Taiwan. sinus.5706@mmh.org.tw.
  • Jhen-Bin Lin
    Department of Radiation Oncology, Changhua Christian Hospital, Changhua, Taiwan.
  • Wan-Chun Lin
    Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Li-Nong St., Beitou District, Taipei, 112304, Taiwan.
  • Ya-Ting Jan
    Department of Radiology, MacKay Memorial Hospital, Taipei, Taiwan.
  • Yi-Shing Leu
    Department of Otolaryngology and Head Neck Surgery, MacKay Memorial Hospital, Taipei, Taiwan.
  • Yu-Jen Chen
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkuo, Taiwan.
  • Kun-Pin Wu
    Institute of Biomedical Informatics, National Yang-Ming University, Taipei 11221, Taiwan.