Serum tryptophan-kynurenine metabolites served as biomarkers of disease activity in rheumatoid arthritis and linked to immune imbalance.

Journal: Arthritis research & therapy
Published Date: Jul 5, 2025

Abstract

BACKGROUND: Immune imbalance caused by imbalanced helper T(Th)17/regulatory T (Treg) and follicular helper T (Tfh)/follicular regulatory T (Tfr) cells drives the onset of rheumatoid arthritis (RA) fundamentally. Tryptophan (Trp) metabolism is crucial in regulating immune and altered Trp metabolism has been reported in RA. However, the potential of altered Trp metabolites to serve as RA-related biomarkers and their relationship to immune balance in RA remains undetermined.

Authors

  • Ruihe Wu
    Department of Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China.
  • Baochen Li
    ChemLex, Shanghai, Shanghai, China.
  • Rui Su
    Huami (Beijing) Information Technology Co. Ltd, Beijing, China.
  • Xiaoyang Liu
    School of Computer Science & Technology, Jiangsu Normal University, Xuzhou 221116, China. Electronic address: liuxiaoyang1979@gmail.com.
  • Anqi Gao
    Department of Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China.
  • Jing Luo
    Department of Ophthalmology, The Second Xiangya Hospital of Central South University, 139 Middle Renmin RD, Changsha, Hunan, China.
  • Chong Gao
    Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Pathology, Boston, MA, USA.
  • Xiaofeng Li
    Department of Otorhinolaryngology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
  • Caihong Wang
    Department of Rheumatology, The Second Hospital of Shanxi Medical University, No. 382 Wu Yi Road, Taiyuan, 030001, Shanxi, China. snwch@sina.com.

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