AIMC Topic: Kynurenine
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Early detection of feline chronic kidney disease via 3-hydroxykynurenine and machine learning.
Scientific reports
Feb 26, 2025
Feline chronic kidney disease (CKD) is one of the most frequently encountered diseases in veterinary practice, and the leading cause of mortality in cats over five years of age. While diagnosing advanced CKD is straightforward, current routine tests ...
Immune-based Machine learning Prediction of Diagnosis and Illness State in Schizophrenia and Bipolar Disorder.
Brain, behavior, and immunity
Aug 14, 2024
BACKGROUND: Schizophrenia and bipolar disorder frequently face significant delay in diagnosis, leading to being missed or misdiagnosed in early stages. Both disorders have also been associated with trait and state immune abnormalities. Recent machine...
Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway.
Oncoimmunology
Nov 26, 2021
Kynurenine (Kyn) is a key inducer of an immunosuppressive tumor microenvironment (TME). Although indoleamine 2,3-dioxygenase (IDO)-selective inhibitors have been developed to suppress the Kyn pathway, the results were not satisfactory due to the pres...
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