AI-based prediction of depression symptomatology in first-episode psychosis patients: insights from the EUFEST and RAISE-ETP clinical trials.

Journal: Psychological medicine
Published Date: Jul 30, 2025

Abstract

BACKGROUND: Depressive symptoms are highly prevalent in first-episode psychosis (FEP) and worsen clinical outcomes. It is currently difficult to determine which patients will have persistent depressive symptoms based on a clinical assessment. We aimed to determine whether depressive symptoms and post-psychotic depressive episodes can be predicted from baseline clinical data, quality of life, and blood-based biomarkers, and to assess the geographical generalizability of these models.

Authors

  • Sergio Mena
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Fiona Coutts
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Jana von Trott
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Esin Ucur
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Clara Vetter
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
  • RenĂ© R Kahn
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria.
  • John M Kane
    The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, United States.
  • Oliver D Howes
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Rachel Upthegrove
    Institute for Mental Health, University of Birmingham, Birmingham, UK.
  • Paris A Lalousis
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Nikolaos Koutsouleris
    Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

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