Risk score stratification of cutaneous melanoma patients based on whole slide images analysis by deep learning.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV
Published Date:

Abstract

BACKGROUND: There is a need to improve risk stratification of primary cutaneous melanomas to better guide adjuvant therapy. Taking into account that haematoxylin and eosin (HE)-stained tumour tissue contains a huge amount of clinically unexploited morphological informations, we developed a weakly-supervised deep-learning approach, SmartProg-MEL, to predict survival outcomes in stages I to III melanoma patients from HE-stained whole slide image (WSI).

Authors

  • Céline Bossard
    Pathology Department, IHP Group, Nantes, France.
  • Yahia Salhi
    DiaDeep, Lyon, France.
  • Amir Khammari
    Department of Dermatology, Nantes University Hospital, Nantes, France.
  • Maud Brousseau
    Pathology Department, IHP Group, Angers, France.
  • Yannick Le Corre
    Pathology Department, IHP Group, Angers, France.
  • Sanae Salhi
    DiaDeep, Lyon, France.
  • Gaëlle Quéreux
    Nantes University, Dermatology Department CHU Nantes CIC 1413, INCIT UMR, Nantes, France.
  • Jérôme J Chetritt
    Pathology Department, IHP Group, Nantes, France.