Anoikis-related genes predicts prognosis and therapeutic response in renal cell carcinoma.

Journal: Annals of medicine
Published Date: Aug 19, 2025

Abstract

BACKGROUND: Metastasis represents the primary cause of cancer-related mortality, with a high incidence observed in renal cell carcinoma (RCC). Anoikis, a specialized form of apoptosis, plays a crucial role in preventing displaced cells from adhering to new extracellular matrices (ECM), thus inhibiting their aberrant growth. Notably, cancer cells, especially metastatic ones, exhibit resistance to anoikis. However, the exact mechanisms of anoikis resistance in RCC are not well understood.

Authors

  • Lizhi Zhou
    Jiangxi Provincial Key Laboratory of Urinary System Diseases, Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P.R. China.
  • Hengcheng Lu
    Cardiovascular Research Institute of Jiangxi Province, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi Provincial, P.R. China.
  • Bin Fu
    Department of Orthopaedic Surgery, Changzhou Wujin People's Hospital, Changzhou 213100, China.
  • Jianhan Fu
    Jiangxi Provincial Key Laboratory of Urinary System Diseases, Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P.R. China.

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