ADAMTS2 mediates epithelial‒mesenchymal transition and inflammation in high-grade serous ovarian cancer: a study based on bioinformatic analyses and experiments.

Journal: BMC cancer
Published Date:

Abstract

BACKGROUND: The importance of epithelial‒mesenchymal transition (EMT) in tumour invasion and metastasis in high-grade serous ovarian cancer (HGSOC) has been highlighted in numerous studies, but genetic biomarkers for predicting EMT in HGSOC are still lacking.

Authors

  • Yunjie Tian
    Department of Gynecology, The Fourth Hospital of Hebei Medical University, No.12 Jiankang Road, Shijiazhuang City, 050000, Hebei Province, China.
  • Jikuan Li
    Department of Vascular Surgery, Hebei General Hospital, No.348 Heping West Road, Xinhua District, Shijiazhuang City, 050000, Hebei Province, China.
  • Ruoyu Dong
    Department of Vascular Surgery, Hebei General Hospital, No.348 Heping West Road, Xinhua District, Shijiazhuang City, 050000, Hebei Province, China.
  • Yingxia Guan
    Department of Obstetrics, The Fourth Hospital of Hebei Medical University, No.12 Jiankang Road, Shijiazhuang City, 050000, Hebei Province, China.
  • Ying Wang
    Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.
  • Longlong Yan
    Department of Pharmacy, Hebei General Hospital, No.348 Heping West Road, Xinhua District, Shijiazhuang City, 050000, Hebei Province, China.
  • Jun Zhang
    First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Shan Kang
    Department of Gynecology, Fourth Hospital Hebei Medical University, Shijiazhuang, China.