Exploring the potential associations between single and mixed volatile compounds and preserved ratio impaired spirometry using five different approaches.

Journal: Ecotoxicology and environmental safety
Published Date: Jul 14, 2025

Abstract

BACKGROUND: Although the relationship between environmental pollutants and respiratory health has received widespread attention, no studies have explored the association between volatile organic compounds (VOCs) and preserved ratio impaired spirometry (PRISm). The Systemic Inflammation Index (SII) is widely recognized as a reliable surrogate marker of systemic inflammatory status and has been identified as a mediating factor correlating various environmental pollutants to respiratory diseases.

Authors

  • Chenyuan Deng
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China. Electronic address: dengcy0758@163.com.
  • Yu Jiang
    School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, China.
  • Yuechun Lin
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
  • Hengrui Liang
    China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Wei Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
  • Ying Huang
    Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Southwest Medical University Luzhou, Sichuan, China.
  • Jianxing He
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.

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