Machine learning developed regulatory T cells-related signature for prognosis and immunotherapy benefit in oral squamous cell carcinoma.

Journal: American journal of otolaryngology
Published Date: May 6, 2025

Abstract

BACKGROUND: Oral squamous cell carcinoma (OSCC) is one of the most common malignancies with poor clinical outcome. Regulatory T cells (Tregs) have a dual role in maintaining immune homeostasis and suppressing anti-tumor immunity. The role of Tregs related genes (TRGs) in the prognosis of OSCC patients were rarely been reported.

Authors

  • Azhu Duan
    Department of stomatology, Shanghai Children's Hospital, Shanghai 200040, China.
  • Yicai Zheng
    Department of Stomatology, Shanghai Fifth People's Hospital, Fudan university, Shanghai 200240, China.
  • Guoxiu Xiao
    Department of Stomatology, Shanghai Fifth People's Hospital, Fudan university, Shanghai 200240, China. Electronic address: xiaoguoxiu@5thhospital.com.

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